Fosforilacija — разлика између измена
Садржај обрисан Садржај додат
мНема описа измене |
мНема описа измене |
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Ред 8:
Foebus A. Leven sa ''Rokfelerovog instituta za medicinska istraživanja'' je [[1906]]. identifikovao fosfat u proteinu [[vitelin]] (fosvitin),<ref name = "Levene_1906">{{cite journal | title = The cleavage products of vitellin | journal = J. Biol. Chem. | volume = 2 | issue = 1 | pages = 127–133 | year = 1906 | month = | doi = | url = http://www.jbc.org/cgi/reprint/2/1/127.pdf | author1 = Levene PA | author2 = Alsberg CL | author-separator = , }}</ref> i do [[1933]] je detektovao fosfoserin u [[kazein]]u, sa Fricom Lipmanom.<ref name = "Lipmann_1932">{{cite journal | title = Serinephosphoric acid obtained on hydrolysis of vitellinic acid | journal = J. Biol. Chem. | volume = 98 | issue = 1 | pages = 109–114 | year = 1932 | month = October| doi = | url = http://www.jbc.org/cgi/reprint/98/1/109.pdf | author1 = Lipmann FA | author2 = Levene PA | author-separator = , }}</ref> Nakon toga je prošlo 20 godina pre nego što je Eugen P. Kenedi opisao prvu ‘enzimatsku fosforilaciju proteina’.<ref name="pmid13221602">{{cite journal | title = The enzymatic phosphorylation of proteins | journal = J. Biol. Chem. | volume = 211 | issue = 2 | pages = 969–80 | year = 1954 | month = December | pmid = 13221602 | doi = | url = http://www.jbc.org/cgi/reprint/211/2/969.pdf | issn = | author1 = Burnett G | author2 = Kennedy EP | author-separator = , }}</ref>
=== Funkcija ===
Reverzibilna fosforilacija proteina je važan regulatorni mehanizam koji se javlja kod [[Prokariote|prokariotskih]] i [[Eukariote|eukariotskih]] organizama.<ref name="Cozzon_1988">{{cite journal | author = Cozzone AJ | title = Protein phosphorylation in prokaryotes | journal = Annu. Rev. Microbiol. | volume = 42 | issue = | pages = 97–125 | year = 1988 | pmid = 2849375 | doi = 10.1146/annurev.mi.42.100188.000525 | url = | issn = }}</ref><ref name="Stock_1989">{{cite journal | title = Protein phosphorylation and regulation of adaptive responses in bacteria | journal = Microbiol. Rev. | volume = 53 | issue = 4 | pages = 450–90 | year = 1989 | month = December | pmid = 2556636 | pmc = 372749 | doi = | url = | issn = | author1 = Stock JB | author2 = Ninfa AJ | author3 = Stock AM | author-separator = , }}</ref><ref name="pmid9662515">{{cite journal | title = The two-component system. Regulation of diverse signaling pathways in prokaryotes and eukaryotes | journal = Plant Physiol. | volume = 117 | issue = 3 | pages = 723–31 | year = 1998 | month = July | pmid = 9662515 | pmc = 1539182 | doi = 10.1104/pp.117.3.723| url = | issn = | author1 = Chang C | author2 = Stewart RC | author-separator = , }}</ref><ref name="pmid9646865">{{cite journal | title = The structure and mechanism of protein phosphatases: insights into catalysis and regulation | journal = Annu Rev Biophys Biomol Struct | volume = 27 | issue = | pages = 133–64 | year = 1998 | pmid = 9646865 | doi = 10.1146/annurev.biophys.27.1.133 | url = | issn = | author1 = Barford D | author2 = Das AK | author3 = Egloff MP | author-separator = , }}</ref>
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