Supstanca P — разлика између измена
Садржај обрисан Садржај додат
Ред 61:
==Otkriće==
Supstancu P su originalno otkrili [[1931]] Ulf von Euler i Džon H. Gadum kao extrakt tkiva koji izaziva intestinalne kontrakcije -{''in vitro''}-.<ref name="pmid16994201">{{cite journal | author = V Euler US, Gaddum JH | title = An unidentified depressor substance in certain tissue extracts | journal = The Journal of Physiology | volume = 72 | issue = 1 | pages = 74–87 | year = 1931 | month = June | pmid = 16994201 | pmc = 1403098 | doi = | url = http://www.jphysiol.org/cgi/pmidlookup?view=long&pmid=16994201 | issn = }}</ref> Njena distribucija u tkivu i biološka dejstva su detaljno ispitivana tokom decenija koje su sledele.<ref name="pmid11378438"/> NKA (predhodno poznata kao supstanca K ili neuromedin L) je izolovana iz [[svinja|svinjske]] [[kičmena moždina|kičmene moždine]] [[1983]], i ustanovljeno je da takođe stimuliše intestinalne kontrakcije.<ref name="pmid6194276">{{cite journal | author = Panula P, Hadjiconstantinou M, Yang HY, Costa E | title = Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons | journal = The Journal of Neuroscience : the official journal of the Society for Neuroscience | volume = 3 | issue = 10 | pages = 2021–9 | year = 1983 | month = October | pmid = 6194276 | doi = | url = http://www.jneurosci.org/cgi/content/abstract/3/10/2021 | issn = }}</ref>
==Receptor==
[[Endogen]]i [[receptor (biohemija)|receptor]] supstance P je [[tahikininski receptor 1|neurokininski 1]] receptor (NK1-receptor, NK1R).<ref name="pmid1657150">{{cite journal | author = Gerard NP, Garraway LA, Eddy RL Jr, Shows TB, Iijima H, Paquet JL, Gerard C | title = Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones | journal = Biochemistry | volume = 30 | issue = 44 | pages = 10640–6 | year = 1991 | month = November | pmid = 1657150 | doi = 10.1021/bi00108a006| url = }}</ref> On pripada familiji [[tahikininski receptor|tahikininskih receptora]] [[GPCR|G protein-spregnutih receptora]].<ref name="pmid7557266">{{cite journal | author = Maggi CA |title = The mammalian tachykinin receptors | journal = Gen. Pharmacol. | volume = 26 | issue = 5 | pages = 911–44 | year = 1995 | pmid = 7557266 | doi = 10.1016/0306-3623(94)00292-U }}</ref>
==Literatura==
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