Keramid — разлика између измена

Postoje tri glavna puta generacije ceramida. Put sfingomijelinaze koristi enzim kiji razlaže [[sfingomijelin]] u ćelijskoj membrani i oslobađa ceramid.<ref name="pmid8046331">{{cite journal |author=Haimovitz-Friedman A, Kan CC, Ehleiter D, ''et al.'' |title=Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis |journal=J. Exp. Med. |volume=180 |issue=2 |pages=525–35 |year=1994 |pmid=8046331 |doi=10.1084/jem.180.2.525 |pmc=2191598}}</ref> De novo put creira ceramid iz manje kompleksnih molekula.<ref name = "pmid18216770">{{cite journal |author=Hannun, Y.A. and Obeid, L.M. |title=Principles of bioactive lipid signalling: lessons from sphingolipids |journal=Nature Reviews: Molecular Cell Biology |volume=9 |pages=139–150 |year=2008 |pmid= 18216770 |doi=10.1038/nrm2329 |issue=2}}</ref> Do formiranja ceramida takođe može doći putem razlaganja kompleksnih [[sfingolipid]]a koji se ultimatno razlažu do [[sfingozin]]a, koji se zatim reacirkuliše čime se formira ceramid. Taj zadnji put se naziva [[Selvidžselvidž put]]em ({{jez-eng-lat|Salvage pathway}}).<ref name = "pmid18191382">{{cite journal |author=Kitatani, K., Idkowiak-Baldys, J., and Hannun, Y.A. |title=The sphingolipid salvage pathway in ceramide metabolism and signaling. |journal=Cell Signaling |volume=30 |issue=6 |pages=1010–1018 |year=2008 |pmid= 18191382 |doi=10.1016/j.cellsig.2007.12.006 |pmc=2422835}}</ref>