P-glikoprotein — разлика између измена

'''P-glikoprotein 1''' (glikoprotein permeabilnosti, -{''P-gp'', ''Pgp''}-, ''protein otpornosti na višestruke lekove 1'', MDR1, ''ATP-vezujuća kaseta potfamilija B član 1'', ABCB1, ''klaster of diferencijacije 243'', -{CD243}-) je [[glikoprotein]] koji je kod ljudi kodiran -{''ABCB1''}- [[gen]]om.<ref name="pmid3027054">{{cite journal | author = Ueda K, Clark DP, Chen CJ, Roninson IB, Michael M. Gottesman, Pastan I | title = The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation | journal = J. Biol. Chem. | volume = 262 | issue = 2 | pages = 505–8 | year = 1987 | month = January | pmid = 3027054 | doi = | url =http://www.jbc.org/cgi/content/abstract/262/2/505 }}</ref> -{P-gp}- dobro poznati [[ABC-transporter]] (koji transportuje široki opseg supstrata kroz ekstra- i intracelularne membrane). On je član [[MultidrugOtpornost resistancena višestruke lekove|MDR]]/[[Transporter associatedasociran withsa antigenobradom processingantigena|TAP]] familije.<ref name="ABC_Transporter_Superfamily">{{cite web | url = http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mono_001.chapter.137 | title = The Human ATP-Binding Cassette (ABC) Transporter Superfamily | accessdate = 2008-03-02 | author = Dean, Michael | authorlink = | coauthors = | date = 2002-11-01 | format = | work = | publisher = National Library of Medicine (US), NCBI | pages = | language = | archiveurl = | archivedate = | quote = }}</ref>