Dopaminski receptor — разлика између измена

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Ред 24:
* '''D<sub>3</sub>''' je kodiran genom [[Dopaminski receptor D3|dopaminskog receptora D<sub>3</sub>]] ({{Gene|DRD3}}). Maksimalno izražavanje dopaminskog D<sub>3</sub> receptora je primećeno u [[Ostrva Kaleha|ostrvima Kaleha]] i -{''[[nucleus accumbens]]''}-.<ref name="Suzuki_1998_D3">{{cite journal | author = Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, Sedvall G | title = D3 dopamine receptor mRNA is widely expressed in the human brain | journal = Brain Res. | volume = 779 | issue = 1-2 | pages = 58–74 | year = 1998 | month = January | pmid = 9473588 | doi = 10.1016/S0006-8993(97)01078-0| url = | issn = }}</ref>
 
* '''D<sub>4</sub>''' je kodiran genom [[Dopaminski receptor D4|dopaminskog receptora D<sub>4</sub>]] ({{Gene|DRD4}}). Gen D<sub>4</sub> receptora manifestuje polimorfizme koji se razlikuju u [[varijabilni broj tandemtandemskih ponavljanja|varijabilnom broju tandemtandemskih ponavljanja]] prisutnih unutar [[Kodirajući region|kodirajuće sekvence]] [[ekson]]a 3.<ref>[http://www.ncbi.nlm.nih.gov/gene/1815?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum#geneReference%20Sequences NCBI Database]</ref> Neki od tih [[alel]]a su povezani sa povećanom učestalošću određenih bolesti. Na primer, D<sub>4.7</sub> aleli imaju uspostavljenu asocijaciju sa [[Hiperkinetički poremećaj|hiperkinetičkim poremećajem]].<ref name="pmid12192625">{{cite journal | author = Manor I, Tyano S, Eisenberg J, Bachner-Melman R, Kotler M, Ebstein RP | title = The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA) | journal = Mol. Psychiatry | volume = 7 | issue = 7 | pages = 790–4 | year = 2002 | pmid = 12192625 | doi = 10.1038/sj.mp.4001078 | url = | issn = }}</ref><ref name="pmid14702261">{{cite journal | author = Langley K, Marshall L, van den Bree M, Thomas H, Owen M, O'Donovan M, Thapar A | title = Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD | journal = Am J Psychiatry | volume = 161 | issue = 1 | pages = 133–8 | year = 2004 | month = January | pmid = 14702261 | doi = 10.1176/appi.ajp.161.1.133| url = | issn = }}</ref><ref name="pmid14699430">{{cite journal | author = Kustanovich V, Ishii J, Crawford L, Yang M, McGough JJ, McCracken JT, Smalley SL, Nelson SF | title = Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5 | journal = Mol. Psychiatry | volume = 9 | issue = 7 | pages = 711–7 | year = 2004 | month = July | pmid = 14699430 | doi = 10.1038/sj.mp.4001466 | url = | issn = }}</ref>
 
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