Metionin sintaza — разлика између измена

25 бајтова уклоњено ,  пре 7 година
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clean up
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'''Metionin sintaza''' ({{EC broj-lat|2.1.1.13}}, ''5-metiltetrahidrofolat-homocisteinska -{S}--metiltransferaza'', ''5-metiltetrahidrofolat-homocisteinska transmetilaza'', ''-{N}--metiltetrahidrofolat:-{L}--homocisteinska metiltransferaza'', ''-{N}-<sup>5</sup>-metiltetrahidrofolatna metiltransferaza'', ''-{N}-<sup>5</sup>-metiltetrahidrofolat-homocistein kobalaminska metiltransferaza'', ''-{N}-<sup>5</sup>-metiltetrahidrofolni-homocistein vitamin B12 transmetilaza'', ''-{B}-<sup>12</sup> -{N}-<sup>5</sup>-metiltetrahidrofolat homocisteinska metiltransferaza'', ''metiltetrahidrofolat-homocistein vitamin B<sub>12</sub> metiltransferaza'', ''tetrahidrofolatna metiltransferaza'', ''tetrahidropteroilglutamatna metiltransferaza'', ''tetrahidropteroilglutaminska metiltransferaza'', ''vitamin B<sub>12</sub> metiltransferaza'', ''kobalamin-zavisna metioninska sintaza'', ''metioninska sintaza (kobalamin-zavisna)'', -{''METH''}-) je [[enzim]] sa sistematskim imenom ''5-metiltetrahidrofolat:-{L}--homocistein -{S}--metiltransferaza''.<ref>{{cite journal | title = The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants |author = Burton, E.G. and Sakami, W. |journal = Biochem. Biophys. Res. Commun. |date = 1969 |volume = 36 |pages = 228-234 |pmid = 5799642}}</ref><ref>{{cite journal | title = Cobalamin and the synthesis of methionine by <em>''Escherichia coli</em>'' |author = Foster, M.A., Dilworth, M.J. and Woods, D.D. |journal = Nature |date = 1964 |volume = 201 |pages = 39-42 |pmid = 14085561}}</ref><ref>{{cite journal | title = Transfer of the methyl group from <em>''N</em>''<small><sup>5</sup></small>-methyltetrahydrofolates to homocysteine in <em>''Escherichia coli</em>'' |author = Guest, J.R., Friedman, S., Foster, M.A., Tejerina, G. and Woods, D.D. |journal = Biochem. J. |date = 1964 |volume = 92 |pages = 497-504 |pmid = 5319972}}</ref><ref>{{cite journal | title = Enzymatic synthesis of the methyl group of methionine. VII. Isolation of a cobalamin-containing transmethylase (5-methyltetrahydro-folate-homocysteine) from mammalian liver |author = Loughlin, R.E., Elford, H.L. and Buchanan, J.M. |journal = J. Biol. Chem. |date = 1964 |volume = 239 |pages = 2888-2895 |pmid = 14216440}}</ref><ref>{{cite journal | title = <em>''Escherichia coli</em>'' B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase: gel-filtration behavior of apoenzyme and holoenzymes |author = Taylor, R.T. |journal = Biochim. Biophys. Acta |date = 1971 |volume = 242 |pages = 355-364 |pmid = 4946148}}</ref><ref>{{cite journal | title = Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin |author = Jarrett, J.T., Huang, S. and Matthews, R.G. |journal = Biochemistry |date = 1998 |volume = 37 |pages = 5372-5382 |pmid = 9548919}}</ref><ref>{{cite journal | title = Characterization of the zinc binding site in methionine synthase enzymes of <em>''Escherichia coli</em>'': The role of zinc in the methylation of homocysteine |author = Peariso, K., Goulding, C.W., Huang, S., Matthews, R.G. and Penner-Hahn, J.E. |journal = J. Am. Chem. Soc. |date = 1998 |volume = 120 |pages = 8410-8416 |pmid = }}</ref><ref>{{cite journal | title = Interaction of flavodoxin with cobalamin-dependent methionine synthase |author = Hall, D.A., Jordan-Starck, T.C., Loo, R.O., Ludwig, M.L. and Matthews, R.G. |journal = Biochemistry |date = 2000 |volume = 39 |pages = 10711-10719 |pmid = 10978155}}</ref><ref>{{cite journal | title = Domain alternation switches B<small><sub>12</sub></small>-dependent methionine synthase to the activation conformation |author = Bandarian, V., Pattridge, K.A., Lennon, B.W., Huddler, D.P., Matthews, R.G. and Ludwig, M.L. |journal = Nat. Struct. Biol. |date = 2002 |volume = 9 |pages = 53-56 |pmid = 11731805}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]
 
: -{S}--metiltetrahidrofolat + -{L}--[[homocistein]] <math>\rightleftharpoons</math> [[tetrahidrofolat]] + -{L}--[[metionin]]