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'''Citrat (Si)-sintaza''' ({{EC broj-lat|2.3.3.1}}, ''(-{R}-)-limunska sintaza'', ''citrat kondenzujući enzim'', ''citrat oksaloacetatna lijaza ((pro-3-{S)-CH2COO}--->acetil-KoA)'', ''citrat oksaloacetatna lijaza, KoA-acetilacija'', ''citratna sintaza'', ''citratna sintetaza'', ''citrik sintaza'', ''citratni kondenzujući enzim'', ''citrogenaza'', ''kondenzujući enzim'', ''oksaloacetatna transacetaza'', ''oksalacetinska transacetaza'') je [[enzim]] sa sistematskim imenom ''acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formirane (pro--{S}-)-karboksimetila)''.<ref>{{cite journal | title = Partial purification and some properties of the (<em>''R</em>'')-citrate synthase from <em>''Clostridium acidi-urici</em>'' |author = Gottschalk, G. |journal = Eur. J. Biochem. |date = 1969 |volume = 7 |pages = 301-306 |pmid = 4974734}}</ref><ref>{{cite journal | title = Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme |author = Ochoa, S., Stern, J.R. and Schneider, M.C. |journal = J. Biol. Chem. |date = 1951 |volume = 193 |pages = 691-702 |pmid = 14907759}}</ref><ref>{{cite book | chapter = Oxalacetate transacetase (condensing enzyme, citrogenase) | title = The Enzymes |author = Stern, J.R. |date = 1961 |volume = 5 |pages = 367-380 |editor = Boyer, P,D., Lardy, H and Myrbäck, K. |edition = 2nd |publisher = Academic Press |location = New York }}</ref><ref>{{cite journal | title = <em>''Azotobacter vinelandii</em>'' citrate synthase |author = Rault-Leonardon, M., Atkinson, M.A., Slaughter, C.A., Moomaw, C.R. and Srere, P.A. |journal = Biochemistry |date = 1995 |volume = 34 |pages = 257-263 |pmid = 7819205}}</ref><ref>{{cite journal | title = Citrate synthase from the hyperthermophilic Archaeon, <em>''Pyrococcus furiosus</em>'' |author = Muir, J.M., Russell, R.J., Hough, D.W. and Danson, M.J. |journal = Prot. Eng. |date = 1995 |volume = 8 |pages = 583-592 |pmid = 8532683}}</ref><ref>{{cite journal | title = The crystal structure of citrate synthase from the hyperthermophilic archaeon <em>''Pyrococcus furiosus</em>'' at 1.9 Å resolution |author = Russell, R.J., Ferguson, J.M., Hough, D.W., Danson, M.J. and Taylor, G.L. |journal = Biochemistry |date = 1997 |volume = 36 |pages = 9983-9994 |pmid = 9254593}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]
: [[acetil-KoA]] + -{H}-<sub>2</sub>O + oksaloacetat <math>\rightleftharpoons</math> [[citrat]] + KoA
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