{{rut}}[[File:Antibiotic sensitvity and resistance.JPG|right|thumb|Testovi antibiotičke otpornosti: [[Bakterija|Bakterije]] u kulturi na levoj strani su podložni antibioticima sadržanim u belim papirinim diskovima. Bakterije u kulturi na desnoj strani su otporni na većinu antibiotika[[antibiotik]]a.]]
'''Otpornost na antibiotike''' je forma [[drugOtpornost resistancena lek|otpornosti na lekove]] wherebypri kojoj someneke (orili, lessređe commonly, allsve) sub-populations of apotpopulacije [[microorganismmikroorganizam]]a, usually aobično [[bacteriabakterija|bakterijskih]]lspeciesvrsta, areimaju ablesposobnost topreživljavanja surviveizlaganja afterjednom exposureili to one or moregrupi [[antibioticantibiotik]]s;a. pathogensPatogeni resistantkoji tosu multipleotporni antibioticsna arevišestruke consideredantibiotike se smatraju ''[[multidrug resistantMultirezistencija|multirezistentnim]]'' ({{jez-eng-lat|multiple drug resistance}}, MDR) orili, more colloquiallykolokvijalno, superbugssuperbakterijama. Microbes,Otpornost ratherna thanlekove people,se developrazvija resistancekod mikroba, a tone antibioticsljudi.<ref name=cdcgetsmart>{{cite web|title=Antibiotic Resistance Questions & Answers|url=http://www.cdc.gov/getsmart/antibiotic-use/antibiotic-resistance-faqs.html#e|work=Get Smart: Know When Antibiotics Work|publisher=Centers for Disease Control and Prevention, USA|accessdate=20 March 2013|date=30|month=June|year=2009}}</ref><ref>{{cite web|author=Snejana Farberov |url=http://www.dailymail.co.uk/news/article-2477273/Weve-reached-end-antibiotics-Top-CDC-expert-declares-miracle-drugs-saved-millions-match-superbugs-people-overmedicated-themselves.html |title='We've reached the end of antibiotics': Top CDC expert declares that 'miracle drugs' that have saved millions are no match against 'superbugs' because people have overmedicated themselves | Mail Online |publisher=Dailymail.co.uk |date= |accessdate=2013-10-28}}</ref>
Otpornost na antibiotike je ozbiljan i rastući fenomen savremene medicine i haspostao emergedje asjednim oneod ofnajeminentnijih thejavnih pre-eminentzdravstvenih publicproblema health21-vog concerns of the 21st centuryveka, particularly as itposebno pertainsu topogledu pathogenicpatogenih organismsorganizama (thetermin termima isposebnu especiallyrelevantanost relevantza toorganizame organismskoji whichuzrokuju causebolesti diseasekod in humansljudi). InU thejednostavnijim simplest casesslučajevima, drug-resistantorganizmi organismsotporni mayna havelekove acquiredsu resistancestekli tootpornost first-linena antibiotike prve antibioticslinije, therebyte necessitatingje theneophodna useprimena ofagenasa second-linedruge agentslinije. TypicallyTipično, aagens first-lineprve agentlinije isse selectedbira onna theosnovu basisnekoliko offaktora severaluključujući factors including safetybezbednost, availabilitydostrupnost andi costcenu; a second-lineagens agentdruge islinije usuallyobično broaderima inširi spectrumspektar, hasmanje apovoljan lessodnos favourableprofila risk-benefitrizika profilei andkoristi isi morevišu expensivecenu. or,U inslučaju direpojedinih circumstancesMDR patogena, bedošlo locallyje unavailable.do Insticanja therezistancije casena ofantibiotike some MDR pathogensdruge, resistanceili točak secondi andtreće evenlinije. third-lineDobar antibioticsprimer istakvog thusorganizma sequentially acquired, a case quintessentially illustrated byje -{''[[Staphylococcus aureus]]''}- inu somepojedinim [[nosocomialБолничке инфекције|nosokomijalnim]] settingssredinama. SomePojedini pathogenspatogeni, such aspoput -{''[[Pseudomonas aeruginosa]]''}-, also possess atakođe highizpoljavaju levelvisok ofnivo intrinsicunutrašnje resistancerezistancije.
