(S)-norkoklaurinska sintaza
(S)-norkoklaurinska sintaza (EC 4.2.1.78, (S)-norlaudanozolinska sintaza, 4-hidroksifenilacetaldehidna hidrolijaza (dodaje dopamin)) je enzim sa sistematskim imenom 4-hidroksifenilacetaldehid hidrolijaza (dodaje dopamin, formira (S)-norkoklaurin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (S)-norkoklaurinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.78 | ||||||||
| CAS broj | 79122-01-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-hidroksifenilacetaldehid + dopamin (S)-norkoklaurin + H2O
Ovom reakcijom nastaje šestočlani prsten putem formiranja veze između C-6 sa 3,4-dihidroksifenilne grupe dopamina i C-1 aldehida u iminu formiranom između supstrata.
Reference уреди
- ^ Stadler, R., Zenk, M.H. (1990). „A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline”. Liebigs Ann. Chem.: 555—562.
- ^ Stadler, R., Kutchan, T.M., Zenk, M.H. (1989). „(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis”. Phytochemistry. 28: 1083—1086.
- ^ Samanani, N. & Facchini, P.J. (2002). „Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants”. J. Biol. Chem. 277: 33878—33883. PMID 12107162.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- (S)-norcoclaurine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
