1-Fosfatidilinozitol 4-kinaza
1-Fosfatidilinozitol 4-kinaza (EC 2.7.1.67, fosfatidilinozitolna kinaza (fosforilacija), fosfatidilinozitolna 4-kinaza, fosfatidilinozitolna kinaza, tip II fosfatidilinozitolna kinaza, PI kinaza, PI 4-kinaza) je enzim sa sistematskim imenom ATP:1-fosfatidil-1D-mio-inozitol 4-fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 1-Fosfatidilinozitol 4-kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Fosfatidilinozitolna 4-kinaza homo16mer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.1.67 | ||||||||
| CAS broj | 37205-54-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovu reakciju katalizuju najmanje dve različite izoforme.
Reference уреди
- ^ Colodzin, M. & Kennedy, E.P. (1965). „Biosynthesis of diphosphoinositide in brain”. J. Biol. Chem. 240: 3771—3780. PMID 4284712.
- ^ Kai, M., White, G.L. and Hawthorne, J.N. (1966). „The phosphatidylinositol kinase of rat brain”. Biochem. J. 101: 328—337. PMID 4290722.
- ^ Walker, D.H., Dougherty, N. and Pike, L.J. (1988). „Purification and characterization of a phosphatidylinositol kinase from A431 cells”. Biochemistry. 27: 6504—6511. PMID 2851325.
- ^ Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L. (1988). „Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate”. Nature. 332: 644—646. PMID 2833705.
- ^ Barylko, B., Gerber, S.H., Binns, D.D., Grichine, N., Khvotchev, M., Sudhof, T.C. and Albanesi, J.P. (2001). „A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans”. J. Biol. Chem. 276: 7705—7708. PMID 11244087.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- 1-phosphatidylinositol+4-kinase на US National Library of Medicine Medical Subject Headings (MeSH)
