Aciredukton dioksigenaza (Fe(2+))
'Aciredukton dioksigenaza (Fe2+) (EC 1.13.11.54, ARD, 2-hidroksi-3-keto-5-tiometilpent-1-en dioksigenaza (nespecifična), aciredukton dioksigenaza (nespecifična), E-2, E-3 dioksigenaza) je enzim sa sistematskim imenom 1,2-dihidroksi-5-(metiltio)pent-1-en-3-one:kiseonik oksidoreduktaza (formira format).[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aciredukton dioksigenaza (Fe2+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.54 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 1,2-dihidroksi-5-(metiltio)pent-1-en-3-on + O2 4-(metiltio)-2-oksobutanoat + format
Ovaj enzim sadrži gvožđe(II). Ako je Ni2+ vezan umesto gvožđa(II), on katalizuje reakciju enzima EC 1.13.11.53, acireduktonske dioksigenaza.
Reference уреди
- ^ Wray, J.W. & Abeles, R.H. (1993). „A bacterial enzyme that catalyzes formation of carbon monoxide”. J. Biol. Chem. 268: 21466—21469. PMID 8407993.
- ^ Wray, J.W. & Abeles, R.H. (1995). „The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases”. J. Biol. Chem. 270: 3147—3153. PMID 7852397.
- ^ Furfine, E.S. & Abeles, R.H. (1988). „Intermediates in the conversion of 5′-S-methylthioadenosine to methionine in Klebsiella pneumoniae”. J. Biol. Chem. 263: 9598—9606. PMID 2838472.
- ^ Dai, Y., Wensink, P.C. and Abeles, R.H. (1999). „One protein, two enzymes”. J. Biol. Chem. 274: 1193—1195. PMID 9880484.
- ^ Mo, H., Dai, Y., Pochapsky, S.S. and Pochapsky, T.C. (1999). „1H, 13C and 15N NMR assignments for a carbon monoxide generating metalloenzyme from Klebsiella pneumoniae”. J. Biomol. NMR. 14: 287—288. PMID 10481280.
- ^ Dai, Y., Pochapsky, T.C. and Abeles, R.H. (2001). „Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae”. Biochemistry. 40: 6379—6387. PMID 11371200.
- ^ Al-Mjeni, F., Ju, T., Pochapsky, T.C. and Maroney, M.J. (2002). „XAS investigation of the structure and function of Ni in acireductone dioxygenase”. Biochemistry. 41: 6761—6769. PMID 12022880.
- ^ Pochapsky, T.C., Pochapsky, S.S., Ju, T., Mo, H., Al-Mjeni, F. and Maroney, M.J. (2002). „Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae”. Nat. Struct. Biol. 9: 966—972. PMID 12402029.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Acireductone+dioxygenase+iron(II) на US National Library of Medicine Medical Subject Headings (MeSH)
