Binospiron

Binospiron
IUPAC ime
	8-[2-(2,3-dihidro-1,4-benzodioksin-2-ilmetilamino)etil]-8-azaspiro[4.5]dekan-7,9-dion
Identifikatori
CAS broj	124756-23-6
ATC kod	none
PubChem	CID 60769
ChemSpider	54766
UNII	T3M5D109V5
Hemijski podaci
Formula	C20H26N2O4
Molarna masa	358,431 g/mol
	SMILES O=C1N(C(=O)CC2(C1)CCCC2)CCNCC3Oc4ccccc4OC3; ;
	InChI InChI=1S/C20H26N2O4/c23-18-11-20(7-3-4-8-20)12-19(24)22(18)10-9-21-13-15-14-25-16-5-1-2-6-17(16)26-15/h1-2,5-6,15,21H,3-4,7-14H2 ; Key:BVMYCHKQPGEOSI-UHFFFAOYSA-N ;

Binospiron (MDL-73,005-EF) je lek koji deluje kao parcijalni agonist na 5-HT_1A somatodendritiskim autoreceptorima, i kao antagonist na postsinaptičkim 5-HT_1A receptorima.^[1] On ima anksiolitsko dejstvo.^[2]

Reference уреди

^ Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). „Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats”. Pharmacology, Biochemistry, and Behavior. 68 (4): 647—60. PMID 11526961. doi:10.1016/S0091-3057(01)00448-8.
^ Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). „Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam”. British Journal of Pharmacology. 99 (2): 343—9. PMC 1917389  . PMID 1970269.

Vidi još уреди

Azapiron

Spoljašnje veze уреди

[1] Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). „Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats”. Pharmacology, Biochemistry, and Behavior. 68 (4): 647—60. PMID 11526961. doi:10.1016/S0091-3057(01)00448-8.

[2] Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). „Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam”. British Journal of Pharmacology. 99 (2): 343—9. PMC 1917389  . PMID 1970269.

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