Citrat (Re)-sintaza
Citrat (Re)-sintaza (EC 2.3.3.3, (R)-citratna sintaza, Re-citratna sintaza, citrat oksaloacetatna lijaza ((pro-3R)-CH2COO--acetil-KoA)) je enzim sa sistematskim imenom acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formiranje (pro-R)-karboksimetila).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Citrat (Re)-sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.3.3 | ||||||||
| CAS broj | 9077-70-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + H2O + oksaloacetat citrat + KoA
Ovaj enzim se inaktivira kiseonikom. On je prisutan kod pojedinih anaeroba.
Reference уреди
- ^ Dittbrenner, S., Chowdhury, A.A. and Gottschalk, G. (1969). „The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate”. Biochem. Biophys. Res. Commun. 36: 802—808. PMID 5808294.
- ^ Gottschalk, G. (1969). „Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici”. Eur. J. Biochem. 7: 301—306. PMID 4974734.
- ^ Gottschalk, G. & Barker, H.A. (1966). „Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase”. Biochemistry. 5: 1125—1133. PMID 5958189.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Citrate+(Re)-synthase на US National Library of Medicine Medical Subject Headings (MeSH)
