Formoterol je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 344,405 Da.[1][2][3][4][5][6][7]

Formoterol
Klinički podaci
Prodajno imeForadil, Foradile, Oxeze Turbuhaler, Oxeze Turbuhaler Foradil
Drugs.comMonografija
Način primeneRespiratorno (inhalacija)
Farmakokinetički podaci
Poluvreme eliminacije10 h
IzlučivanjeRenalno
Identifikatori
CAS broj73573-87-2 ДаY
ATC kodR03AC13 (WHO)
PubChemCID 3410
IUPHAR/BPS3465
DrugBankDB00983 ДаY
ChemSpider3292 ДаY
KEGGC07805 ДаY
ChEMBLCHEMBL1363 ДаY
Hemijski podaci
FormulaC19H24N2O4
Molarna masa344,405
  • COC1=CC=C(CC(C)NCC(O)C2=CC(NC=O)=C(O)C=C2)C=C1
  • InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22) ДаY
  • Key:BPZSYCZIITTYBL-UHFFFAOYSA-N ДаY

Osobine уреди

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 4
Broj rotacionih veza 8
Particioni koeficijent[8] (ALogP) 1,9
Rastvorljivost[9] (logS, log(mol/L)) -4,4
Polarna površina[10] (PSA, Å2) 90,8

Reference уреди

  1. ^ Bartow RA, Brogden RN: Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma. Drugs. 1998 Feb;55(2):303-22. PMID 9506248
  2. ^ Cheer SM, Scott LJ: Formoterol: a review of its use in chronic obstructive pulmonary disease. Am J Respir Med. 2002;1(4):285-300. PMID 14720051
  3. ^ Steiropoulos P, Tzouvelekis A, Bouros D: Formoterol in the management of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3(2):205-15. PMID 18686730
  4. ^ Faulds D, Hollingshead LM, Goa KL: Formoterol. A review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease. Drugs. 1991 Jul;42(1):115-37. PMID 1718682
  5. ^ Op't Holt TB: Inhaled beta agonists. Respir Care. 2007 Jul;52(7):820-32. PMID 17594727
  6. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  7. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди
  8. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  9. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди
  10. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди

Literatura уреди

Spoljašnje veze уреди


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