HMOX2

Hem oksigenaza 2 je enzim koji je kod ljudi kodiran HMOX2 genom.

HMOX2
Available structures PDB Pretraga ortologa: PDBe RCSB List of PDB id codes 2Q32, 2QPP, 2RGZ, 4WMH
Identifikatori
Alijasi	HMOX2
Spoljašnji ID	OMIM: 141251 MGI: 109373 HomoloGene: 1611 GeneCards: HMOX2
Genska lokacija (miš) Hr. Chromosome 16 (mouse) Band 16 A1|16 2.46 cM Start 4,544,225 bp Kraj 4,584,606 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • oxidoreductase activity • GO:0001948, GO:0016582 везивање за протеине плазме • metal ion binding • heme oxygenase (decyclizing) activity • heme binding Cellular component • intracellular membrane-bounded organelle • endoplasmic reticulum membrane • мембрана • ендоплазматични ретикулум • ћелијска мембрана • specific granule membrane Biological process • реакција на хипоксију • cellular iron ion homeostasis • heme oxidation • GO:0001306 response to oxidative stress • heme catabolic process • neutrophil degranulation • iron ion homeostasis Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	3163	15369
Ensembl	ENSG00000277424 ENSG00000103415	ENSMUSG00000004070
UniProt	P30519	O70252
RefSeq (mRNA)	NM_001127204 NM_001127205 NM_001127206 NM_001286267 NM_001286268 NM_001286269 NM_001286270 NM_001286271 NM_002134	NM_001136066 NM_010443 NM_001357050 NM_001378999
RefSeq (protein)	NP_001120676 NP_001120677 NP_001120678 NP_001273196 NP_001273197 NP_001273198 NP_001273199 NP_001273200 NP_002125	NP_001129538 NP_034573 NP_001343979 NP_001365928
Location (UCSC)	n/a	Chr 16: 4.54 – 4.58 Mb
PubMed search
Wikidata
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Funkcija

Hem oksigenaza je esencijalni enzim katabolizma hema, koji razlaže hem do biliverdina, koji naknadno biva konvertovan do bilirubina posredstvm biliverdinske reduktaze, i ugljen-monoksida, potencijalnih neurotransmitera. Dejstvo hem oksigenaze indukuje njen supstarat hem i razne nehemne supstance. Hem oksigenaze se javljaju kao dva izozima, inducibilna hem oksigenaza-1 i konstitutivna hem oksigenaza-2. HMOX1 i HMOX2 (ovaj enzim) propadaju familiji hem oksigenaza.

Literatura

• Bianchetti CM, Yi L, Ragsdale SW, Phillips GN (2007). „Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2”. J Biol Chem. 282 (52): 37624—31. PMC 2896506 . PMID 17965015. doi:10.1074/jbc.M707396200. 
• Wang J, Zhuang H, Doré S (2006). „Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage.”. Neurobiol Dis. 22 (3): 473—6. PMID 16459095. doi:10.1016/j.nbd.2005.12.009. 
• Wang J, Doré S (2008). „Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage.”. Neuroscience. 155 (4): 1133—41. PMID 18674596. doi:10.1016/j.neuroscience.2008.07.004. 
• Barañano DE, Snyder SH (2001). „Neural roles for heme oxygenase: Contrasts to nitric oxide synthase”. Proc. Natl. Acad. Sci. U.S.A. 98 (20): 10996—1002. PMC 58673 . PMID 11572959. doi:10.1073/pnas.191351298. 
• Doré S (2002). „Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease”. Free Radic. Biol. Med. 32 (12): 1276—82. PMID 12057765. doi:10.1016/S0891-5849(02)00805-5. 
• Kemp PJ (2005). „Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction”. Biochem. Biophys. Res. Commun. 338 (1): 648—52. PMID 16137652. doi:10.1016/j.bbrc.2005.08.110. 
• Ishikawa K, Takeuchi N, Takahashi S, Matera KM, Sato M, Shibahara S, Rousseau DL, Ikeda-Saito M, Yoshida T (1995). „Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2”. J. Biol. Chem. 270 (11): 6345—50. PMID 7890772. doi:10.1074/jbc.270.11.6345. 
• Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B (1994). „Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3”. Genomics. 20 (3): 513—6. PMID 8034330. doi:10.1006/geno.1994.1213. 
• Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
• Takahashi K, Hara E, Suzuki H, Sasano H, Shibahara S (1996). „Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors”. J. Neurochem. 67 (2): 482—9. PMID 8764571. doi:10.1046/j.1471-4159.1996.67020482.x. 
• Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S (1997). „Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1”. Cytogenet. Cell Genet. 77 (3–4): 180—1. PMID 9284910. doi:10.1159/000134570. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
• Yoshiki N, Kubota T, Aso T (2000). „Expression and localization of heme oxygenase in human placental villi”. Biochem. Biophys. Res. Commun. 276 (3): 1136—42. PMID 11027601. doi:10.1006/bbrc.2000.3551. 
• Hanselmann C, Mauch C, Werner S (2001). „Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?”. Biochem. J. 353 (Pt 3): 459—66. PMC 1221590 . PMID 11171041. doi:10.1042/0264-6021:3530459. 
• Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH, Lash GE (2003). „Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells”. Am. J. Physiol. Heart Circ. Physiol. 284 (3): H853—8. PMID 12578814. doi:10.1152/ajpheart.00655.2002. 
• Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (2003). „Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes”. J. Neurovirol. 9 (3): 358—71. PMID 12775419. doi:10.1080/13550280390201119. 
• Zenclussen AC, Lim E, Knoeller S, Knackstedt M, Hertwig K, Hagen E, Klapp BF, Arck PC (2004). „Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies”. Am. J. Reprod. Immunol. 50 (1): 66—76. PMID 14506930. doi:10.1034/j.1600-0897.2003.00047.x. 
• Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, Snyder SH (2003). „Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2”. Neuron. 40 (1): 129—37. PMID 14527438. doi:10.1016/S0896-6273(03)00596-8. 
• Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH (2004). „Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells”. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (6): R1453—60. PMID 14615405. doi:10.1152/ajpregu.00234.2003.