Matrilizin
Matrilizin (EC 3.4.24.23, matrin, uterinska metaloendopeptidaza, matriks metaloproteinaza 7, matriks metaloproteinazna pumpa 1, MMP 7, PUMP-1 proteinaza, PUMP, metaloproteinazna pumpa-1, MMP) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Matrilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.23 | ||||||||
| CAS broj | 141256-52-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Razlaganje Ala14-Leu i Tyr16-Leu u B lancu insulina. Ne dolazi do razlaganja kolagenskih tipova I, II, IV, V. Razlaže se želatinski lanac alfa2(I) > alfa1(I)
Ovaj enzim je prisutan u materici pacova.
Reference уреди
- ^ Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J. and Breathnach, R. (1988). „The collagenase gene family in humans consists of at least four members”. Biochem. J. 253: 187—192. PMID 2844164.
- ^ Woessner, J.F., Jr. & Taplin, C.J. (1988). „Purification and properties of a small latent matrix metalloproteinase of the rat uterus”. J. Biol. Chem. 263: 16918—16925. PMID 3182822.
- ^ Quantin, B., Murphy, G. and Breathnach, R. (1989). „Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members”. Biochemistry. 28: 5327—5334. PMID 2550050.
- ^ Miyazaki, K., Hattori, Y., Umenishi, F., Yasumitsu, H. and Umeda, M. (1990). „Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line”. Cancer Res. 50: 7758—7764. PMID 2253219.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Matrilysin на US National Library of Medicine Medical Subject Headings (MeSH)
