Neoabietadienska sintaza
Neoabietadienska sintaza (EC 4.2.3.132, AgAS, PtTPS-LAS) je enzim sa sistematskim imenom (+)-copali-difosfat difosfat-lijaza (ciklizacija, formira neoabietadien).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Neoabietadienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.132 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (+)-kopalil difosfat neoabietadien + difosfat
Ovaj enzim je izolovan iz Abies grandis.
Reference уреди
- ^ Peters, R.J., Flory, J.E., Jetter, R., Ravn, M.M., Lee, H.J., Coates, R.M. and Croteau, R.B. (2000). „A'bietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme”. Biochemistry. 39: 15592—15602. PMID 11112547.
- ^ Zhou, K., Gao, Y., Hoy, J.A., Mann, F.M., Honzatko, R.B. and Peters, R.J. (2012). „Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis”. J. Biol. Chem. 287: 6840—6850. PMID 22219188.
- ^ Ro, D.K. & Bohlmann, J. (2006). „Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)”. Phytochemistry. 67: 1572—1578. PMID 16497345.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Neoabietadiene+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
