(Heparan sulfat)-glukozamin 3-sulfotransferaza 1
(heparan sulfat)-glukozamin 3-sulfotransferaza 1 (EC 2.8.2.23, heparin-glukozaminska 3-O-sulfotransferaza, 3'-fosfoadenilil-sulfat:heparin-glukozamin 3-O-sulfotransferaza, glukozaminilna 3-O-sulfotransferaza, heparan sulfat D-glukozaminilna 3-O-sulfotransferaza, izoform/izozim 1 (3-OST-1, HS3ST1)) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin 3-sulfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (heparan sulfat)-glukozamin 3-sulfotransferaza 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.23 | ||||||||
| CAS broj | 183257-54-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-glukozamin 3-sulfat
Ovaj enzim je veoma selektivan za prekurzor antitrombin-vezujućeg mesta.
Reference уреди
- ^ Kusche, M., Backström, G., Riesenfeld, J., Pepitou, M., Choay, J. and Lindahl, U. (1988). „Biosynthesis of heparin. O-Sulfation of the antithrombin-binding region”. J. Biol. Chem. 263: 15474—15484. PMID 3139669.
- ^ Shworak, N.W., Fritze, L.M.S., Liu, J., Butler, L.D. and Rosenberg, R.D. (1996). „Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting activity which modifies a nonlimiting precursor pool”. J. Biol. Chem. 271: 27063—27071. PMID 8900197.
- ^ Liu, J., Shworak, N.W., Fritze, L.M.S., Edelberg, J.M. and Rosenberg, R.D. (1996). „Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase”. J. Biol. Chem. 271: 27072—27082. PMID 8900198.
- ^ Shworak, N.W., Liu, J., Fritze, L.M.S., Schwartz, J.J., Zhang, L., Logeart, D. and Rosenberg, R.D. (1997). „Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase”. J. Biol. Chem. 272: 28008—28019. PMID 9346953.
- ^ Zhang, L., Yoshida, K., Liu, J. and Rosenberg, R.D. (1999). „Anticoagulant heparan sulfate precursor structures in F9 embryonal carcinoma cells”. J. Biol. Chem. 274: 5681—5691. PMID 10026187.
- ^ Zhang, L., Lawrence, R., Schwartz, J.J., Bai, X. (2001). „, Wei., G, Esko, J.D. and Rosenberg, R.D. The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate”. J. Biol. Chem. 276: 28806—28813. PMID 11375390.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- (heparan+sulfate)-glucosamine+3-sulfotransferase+1 на US National Library of Medicine Medical Subject Headings (MeSH)
