Отворите главни мени

(heparan sulfat)-glukozamin 3-sulfotransferaza 1 (EC 2.8.2.23, heparin-glukozaminska 3-O-sulfotransferaza, 3'-fosfoadenilil-sulfat:heparin-glukozamin 3-O-sulfotransferaza, glukozaminilna 3-O-sulfotransferaza, heparan sulfat D-glukozaminilna 3-O-sulfotransferaza, izoform/izozim 1 (3-OST-1, HS3ST1)) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin 3-sulfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(heparan sulfat)-glukozamin 3-sulfotransferaza 1
Identifikatori
EC broj2.8.2.23
CAS broj183257-54-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum
3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-glukozamin 3-sulfat

Ovaj enzim je veoma selektivan za prekurzor antitrombin-vezujućeg mesta.

ReferenceУреди

  1. ^ Kusche, M., Backström, G., Riesenfeld, J., Pepitou, M., Choay, J. and Lindahl, U. (1988). „Biosynthesis of heparin. O-Sulfation of the antithrombin-binding region”. J. Biol. Chem. 263: 15474—15484. PMID 3139669. 
  2. ^ Shworak, N.W., Fritze, L.M.S., Liu, J., Butler, L.D. and Rosenberg, R.D. (1996). „Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting activity which modifies a nonlimiting precursor pool”. J. Biol. Chem. 271: 27063—27071. PMID 8900197. 
  3. ^ Liu, J., Shworak, N.W., Fritze, L.M.S., Edelberg, J.M. and Rosenberg, R.D. (1996). „Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase”. J. Biol. Chem. 271: 27072—27082. PMID 8900198. 
  4. ^ Shworak, N.W., Liu, J., Fritze, L.M.S., Schwartz, J.J., Zhang, L., Logeart, D. and Rosenberg, R.D. (1997). „Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase”. J. Biol. Chem. 272: 28008—28019. PMID 9346953. 
  5. ^ Zhang, L., Yoshida, K., Liu, J. and Rosenberg, R.D. (1999). „Anticoagulant heparan sulfate precursor structures in F9 embryonal carcinoma cells”. J. Biol. Chem. 274: 5681—5691. PMID 10026187. 
  6. ^ Zhang, L., Lawrence, R., Schwartz, J.J., Bai, X. (2001). „, Wei., G, Esko, J.D. and Rosenberg, R.D. The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate”. J. Biol. Chem. 276: 28806—28813. PMID 11375390. 

LiteraturaУреди

Spoljašnje vezeУреди