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(piruvat dehidrogenaza (acetil-transfer)) kinaza (EC 2.7.11.2, PDH kinaza, PDHK, PDK, PDK1, PDK2, PDK3, PDK4, piruvatna dehidrogenaza kinaza, piruvat dehidrogenaza kinaza (fosforilacija), piruvat dehidrogenaza kinaza activator protein, STK1) je enzim sa sistematskim imenom ATP:(piruvat dehidrogenaza (acetil-transfer)) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(piruvat dehidrogenaza (acetil-transfer)) kinaza
Pyruvate dehydrogenase phosphorylation sites.png
Identifikatori
EC broj2.7.11.2
CAS broj2620256
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum
ATP + [piruvat dehidrogenaza (acetil-transfer)] ADP + [piruvat dehidrogenaza (acetil-transfer)] fosfat

Ovaj enzim nema aktivirajuće jedinjenje, ali je specifičan za svoj supstrat.

ReferenceУреди

  1. ^ Linn, T.C., Pelley, J.W., Petit, F.H., Hucho, F., Randall, D.D. and Reed, L.J. (1972). „α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart”. Arch. Biochem. Biophys. 148: 327—342. PMID 4401694. 
  2. ^ Reed, L.J., Damuni, Z. and Merryfield, M.L. (1985). „Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation”. Curr. Top. Cell. Regul. 27: 41—49. PMID 3004826. 
  3. ^ Tovar-Mendez, A., Hirani, T.A., Miernyk, J.A. and Randall, D.D. (2005). „Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase”. Arch. Biochem. Biophys. 434: 159—168. PMID 15629119. 
  4. ^ Bao, H., Kasten, S.A., Yan, X., Hiromasa, Y. and Roche, T.E. (2004). „Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP”. Biochemistry. 43: 13442—13451. PMID 15491151. 
  5. ^ Roche, T.E., Hiromasa, Y., Turkan, A., Gong, X., Peng, T., Yan, X., Kasten, S.A., Bao, H. and Dong, J. (2003). „Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1”. Eur. J. Biochem. 270: 1050—1056. PMID 12631265. 

LiteraturaУреди

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