Steroid 21-monooksigenaza
(преусмерено са 21-hidroksilaza)
Steroid 21-monooksigenaza (EC 1.14.99.10, steroidna 21-hidroksilaza, 21-hidroksilaza) je enzim sa sistematskim imenom steroid,vodonik-donor:kiseonik oksidoreduktaza (21-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Steroid 21-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.10 | ||||||||
| CAS broj | 9029-68-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- steroid + AH2 + O2 21-hidroksisteroid + A + H2O
Ovaj enzimski sistem obuhvata hem-tiolatni protein (P-450) i flavoprotein.
Reference уреди
- ^ Hayano, M. & Dorfman, R.I. (1952). „The action of adrenal homogenates on progesterone, 17-hydroxyprogesterone and 21-desoxycortisone”. Arch. Biochem. Biophys. 36: 237—239. PMID 14934270.
- ^ Plager, J.E. & Samuels, L.T. (1953). „Synthesis of C14-17-hydroxy-11-desoxycorticosterone and 17-hydroxycorticosterone by fractionated extracts of adrenal homogenates”. Arch. Biochem. Biophys. 42: 477—478. PMID 13031650.
- ^ Ryan, K.J. & Engel, L.L. (1957). „Hydroxylation of steroids at carbon 21”. J. Biol. Chem. 225: 103—114. PMID 13416221.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Steroid+21-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
