Adenozilkobinamid-fosfatna sintaza
(преусмерено са Adenozilkobinamid-fosfat sintaza)
Adenozilkobinamid-fosfatna sintaza (EC 6.3.1.10, CbiB) je enzim sa sistematskim imenom adenozilkobirinska kiselina:(R)-1-aminopropan-2-il fosfat ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Adenozilkobinamid-fosfatna sintaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 6.3.1.10 | ||||||||
| CAS broj | 905988-16-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (1) ATP + adenozilkobirinska kiselina + (R)-1-aminopropan-2-il fosfat ADP + fosfat + adenozilkobinamid fosfat
- (2) ATP + adenozilkobirinska kiselina + (R)-1-aminopropan-2-ol ADP + fosfat + adenozilkobinamid
Jedan od supstrata ove reakcije, (-{R]-)-1-aminopropan-2-il fosfat, se formira posredstvom enzima CobD (EC 4.1.1.81, treonin-fosfat dekarboksilaze).
Reference уреди
- ^ Cheong, C.G., Bauer, C.B., Brushaber, K.R., Escalante-Semerena, J.C. and Rayment, I. (2002). „Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica”. Biochemistry. 41: 4798—4808. PMID 11939774.
- ^ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390—412. PMID 12195810.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Adenosylcobinamide-phosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
