D-prolin reduktaza (ditiol)
D-prolin reduktaza (ditiol) (EC 1.21.4.1, D-proline reductase (dithiol)) je enzim sa sistematskim imenom 5-aminopentanoat:lipoat oksidoreduktaza (ciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| D-prolin reduktaza (ditiol) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.4.1 | ||||||||
| CAS broj | 37255-43-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 5-aminopentanoat + lipoat D-prolin + dihidrolipoat
Reakcija se odviaj u smeru redukcije D-prolina. Drugi ditioli mogu da deluju kao redukujući agensi.
Reference уреди
- ^ Hodgins, D.S. & Abeles, R.H. (1969). „Studies of the mechanism of action of D-proline reductase: the presence on covalently bound pyruvate and its role in the catalytic process”. Arch. Biochem. Biophys. 130: 274—285. PMID 5778643.
- ^ Stadtman, T.C. & Elliott, P. (1957). „Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii”. J. Biol. Chem. 228: 983—997. PMID 13475375.
- ^ Kabisch, U.C., Gräntzdörffer, A., Schierhorn, A., Rücknagel, K.P, Andreesen, J.R. and Pich, A. (1999). „Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein”. J. Biol. Chem. 274: 8445—8454. PMID 10085076.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- D-proline+reductase+(dithiol) на US National Library of Medicine Medical Subject Headings (MeSH)
