L-AP4

L-AP4
IUPAC ime
	(2S)-2-amino-4-fosfonobutanoinska kiselina
Identifikatori
CAS broj	23052-81-5
ATC kod	none
PubChem	CID 179394
IUPHAR/BPS	1412
Hemijski podaci
Formula	C4H10NO5P
Molarna masa	183,099 g/mol
	SMILES OC(=O)C(N)CCP(O)(O)=O; ;

L-AP4 je lek koji se koristi u naučnim istraživanjima. On deluje kao agonist koji je selektivan za grupu III metabotropnih glutamatnih receptora (mGluR₄_/₆_/₇_/₈). On je bio privi ligand za koji je utvrđeno da deluje kao selektivni agonist za ovu grupu mGlu receptora.^[1] On se koristi u izučavanju ove receptorske familije i njihovih funkcija.^[2]^[3]^[4]^[5]

Reference уреди

^ Thomsen C (1997). „The L-AP4 receptor”. General pharmacology. 29 (2): 151—8. PMID 9251893.
^ Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (2007). „Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease”. Journal of Neuroscience. 27 (25): 6701—11. PMID 17581957. doi:10.1523/JNEUROSCI.0299-07.2007.
^ MacInnes N, Duty S (2008). „Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo”. European journal of pharmacology. 580 (1–2): 95—9. PMID 18035348. doi:10.1016/j.ejphar.2007.10.030.
^ Zhang HM, Chen SR, Pan HL (2009). „Effects of Activation of Group III Metabotropic Glutamate Receptors on Spinal Synaptic Transmission in a Rat Model of Neuropathic Pain”. Neuroscience. 158 (2): 875—84. PMC 2649787  . PMID 19017536. doi:10.1016/j.neuroscience.2008.10.042.
^ MacIejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, Lehner M, Bidziński A, Hamed A (2009). „The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration”. Brain research. 1282: 20—7. PMID 19481536. doi:10.1016/j.brainres.2009.05.049.

Spoljašnje veze уреди

[1] Thomsen C (1997). „The L-AP4 receptor”. General pharmacology. 29 (2): 151—8. PMID 9251893.

[2] Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (2007). „Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease”. Journal of Neuroscience. 27 (25): 6701—11. PMID 17581957. doi:10.1523/JNEUROSCI.0299-07.2007.

[3] MacInnes N, Duty S (2008). „Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo”. European journal of pharmacology. 580 (1–2): 95—9. PMID 18035348. doi:10.1016/j.ejphar.2007.10.030.

[4] Zhang HM, Chen SR, Pan HL (2009). „Effects of Activation of Group III Metabotropic Glutamate Receptors on Spinal Synaptic Transmission in a Rat Model of Neuropathic Pain”. Neuroscience. 158 (2): 875—84. PMC 2649787  . PMID 19017536. doi:10.1016/j.neuroscience.2008.10.042.

[5] MacIejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, Lehner M, Bidziński A, Hamed A (2009). „The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration”. Brain research. 1282: 20—7. PMID 19481536. doi:10.1016/j.brainres.2009.05.049.

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