MPPF

MPPF
Nazivi
	IUPAC naziv 4-Fluoro-N-[2-[4-(2-metoksifenil)-1-piperazinil]etil]-N-(2-piridil)benzamid
Identifikacija
CAS broj	155204-26-5;
3D model (Jmol)	interaktivna slika;
PubChem C ID	6603915;
	SMILES COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4=CC=C(C=C4)F; ; ; ; ; ;
Svojstva
Hemijska formula	C25H27FN4O2
Molarna masa	434,51 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

MPPF (2'-metoksifenil-(N-2'-piridinil)-p-fluoro-benzamidoetilipiperazin) je jedinjenje koje se vezuje za serotoninski 1A receptor. Obeležen sa fluorom-18 on je korišten kao radioligand za pozitronsku emisionu tomografiju.^[3] On je između ostalog bio korišten za ispitivanje razlika vezivanja za neuroreceptore u ljudskom mozgu kod osoba različitog pola i uzrasta.^[4]

Vidi još уреди

WAY-100,635

Reference уреди

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ D. Le Bars (1998). „High-Yield Radiosynthesis and Preliminary In Vivo Evaluation of p-18FMPPF, a Fluoro Analog of WAY-100635”. Nuclear Medicine and Biology. 25 (4): 343–350. doi:10.1016/S0969-8051(97)00229-1.
^ Nicolas Costes; Merlet, I; Ostrowsky, K; Faillenot, I; Lavenne, F; Zimmer, L; Ryvlin, P; Le Bars, D (2005). „A18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging”. the Journal of Nuclear Medicine. 46 (12): 1980–1989. PMID 16330560.

Spoljašnje veze уреди

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] D. Le Bars (1998). „High-Yield Radiosynthesis and Preliminary In Vivo Evaluation of p-18FMPPF, a Fluoro Analog of WAY-100635”. Nuclear Medicine and Biology. 25 (4): 343–350. doi:10.1016/S0969-8051(97)00229-1.

[4] Nicolas Costes; Merlet, I; Ostrowsky, K; Faillenot, I; Lavenne, F; Zimmer, L; Ryvlin, P; Le Bars, D (2005). „A18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging”. the Journal of Nuclear Medicine. 46 (12): 1980–1989. PMID 16330560.

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