N-acetillaktozamin sintaza
N-acetillaktozamin sintaza (EC 2.4.1.90, UDP-galaktoza N-acetilglukozamin beta-D-galaktoziltransferaza, uridin difosfogalaktoza-acetilglukozamin galaktoziltransferaza, beta-1,4-galaktoziltransferaza, acetillaktozamin sintetaza, laktozamin sintaza, laktozamin sintetaza, laktoza sintetaza A protein, N-acetillaktozamin sintetaza, UDP-galaktoza N-acetilglukozamin beta-4-galaktoziltransferaza, UDP-galaktoza-acetilglukozamin galaktoziltransferaza, UDP-galaktoza-N-acetilglukozamin beta-1,4-galaktoziltransferaza, UDP-galaktoza-N-acetilglukozamin galaktoziltransferaza, beta1-4-galaktoziltransferaza, UDP-Gal:N-acetilglukozamin beta1-4-galaktoziltransferaza, beta1-4GalT, NAL sintetaza, UDP-beta-1,4-galaktoziltransferaza, Gal-T, UDP-galaktoza:N-acetilglukozaminide beta1-4-galaktoziltransferaza, UDPgalaktoza:N-acetilglukozaminil(beta1-4)galaktoziltransferaza, beta-N-acetilglukozaminide beta1-4-galaktoziltransferaza, UDP-galaktoza:N-acetil-D-glukozamin 4-beta-D-galaktoziltransferaza) je galaktozil-transferazni enzim sa sistematskim imenom UDP-alfa-D-galaktoza:N-acetil-D-glukozamin 4-beta-D-galaktoziltransferaza.[1][2][3][4][5][6] On je komponenta laktozne sintaze.[7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N-acetillaktozamin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.90 | ||||||||
| CAS broj | 9054-94-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-alfa-D-galaktoza + N-acetil-D-glukozamin UDP + N-acetillaktozamin
Ovu reakciju katalizuje komponenta enzima EC 2.4.1.22 (laktozna sintaze), koja je identična sa EC 2.4.1.38 (beta-N-acetilglukozaminil-glikopeptid beta-1,4-galaktoziltransferazom), i enzim iz Goldžijevog aparata životinjskih tkiva.
Vidi još
уредиReference
уреди- ^ Deshmukh DS, Bear WD, Soifer D (1978). „Isolation and characterization of an enriched Golgi fraction from rat brain”. Biochim. Biophys. Acta. 542: 284—295. PMID 99178.
- ^ Helting, T. & Erbing, B. (1973). „Galactosyl transfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase”. Biochim. Biophys. Acta. 293: 94—104. PMID 4631039.
- ^ Hill, R.L. & Brew, K. (1975). „Lactose synthetase”. Adv. Enzymol. Relat. Areas Mol. Biol. 43: 411—490. PMID 812340.
- ^ Humphreys-Beher, M.G. (1984). „Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 β-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol”. J. Biol. Chem. 259: 5797—5802. PMID 6201486.
- ^ Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S (1970). „Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction”. J. Biol. Chem. 245: 1090—1100. PMID 4392041.
- ^ Naoyuki Taniguchi; Koichi Honke; Minoru Fukuda (2002). Handbook of glycosyltransferases and related genes (1st изд.). Springer. ISBN 443170311X.
- ^ Webb, Edwin C. (1992). Enzyme nomenclature 1992: recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the nomenclature and classification of enzymes. San Diego: Published for the International Union of Biochemistry and Molecular Biology by Academic Press. ISBN 0-12-227164-5.
- ^ Funderburgh, James L. (2000). „Mini reveiw, Keratan sulfate: structure, biosynthesis, and function”. Glycobiology. 10: 951—958. doi:10.1093/glycob/10.10.951.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
- Webb, Edwin C. (1992). Enzyme nomenclature 1992: recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the nomenclature and classification of enzymes. San Diego: Published for the International Union of Biochemistry and Molecular Biology by Academic Press. ISBN 0-12-227164-5.
Spoljašnje veze
уреди- N-acetyllactosamine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
