Opioid
Opioid je hemijsko jedinjenje koje se vezuje za opioidne receptore, koji se nalaze prvenstveno u centralnom nervnom sistemu i gastrointestinalnom traktu. Ovi receptori u tim organima posreduju blagotvorne kao i sporedne efekte opioida.[1][2]
Analgetski efekti opioida dolaze os umanjenog percepcije bola, umanjene reakcije na bol kao i povećane tolerancije bola. Nepoželjni efekti opioida su sedacija, respiratorna depresija, i konstipacija. Opioidi mogu da uzrokuju umanjenje kašlja. Fizička zavisnost može da se razvije tokom njihove administracije, koja dovodi do sindroma povlačenja kod naglog prekida upotrebe. Opioidi mogu da proizvedu osećanje euforije.
Vidi još
уредиLiteratura
уреди- ^ Chevlen, E. (2003). „Opioids: a review”. Curr Pain Headache Rep. 7 (1): 15—23. PMID 12525266. doi:10.1007/s11916-003-0005-5.
- ^ Pasternak, G. W. (2010). „Molecular insights into mu opioid pharmacology: From the clinic to the bench”. Clin J Pain. 26 Suppl 10 (Suppl 10): S3—9. PMC 2810866
. PMID 20026962. doi:10.1097/AJP.0b013e3181c49d2e.
Dodatna literatura
уреди- Palliativedrugs.com Palliative Care Formulary and bulletin board with over 22,000 worldwide registered. Free to register.
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- Rossi S (ур.). Australian Medicines Handbook 2005. ISBN 0-9578521-9-3.. Adelaide: Australian Medicines Handbook. .
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- Hanks G, Cherny NI, Calman K (ур.). Oxford Textbook of Palliative Medicine (3rd изд.). Doyle D.. Oxford : Oxford University Press, 2003.
- Hanks, G. W.; Conno, F.; Cherny, N.; Hanna, M.; Kalso, E.; McQuay, H. J.; Mercadante, S.; Meynadier, J.; Poulain, P.; Ripamonti, C.; Radbruch, L.; Casas, J. R.; Sawe, J.; Twycross, R. G.; Ventafridda, V.; Expert Working Group of the Research Network of the European Association for Palliative Care (2001). „Morphine and alternative opioids in cancer pain: The EAPC recommendations”. British Journal of Cancer. 84 (5): 587—93. PMC 2363790 . PMID 11237376. doi:10.1054/bjoc.2001.1680..
- Twycross, R. G.; Wilcock A. (2001). Symptom Management in Advanced Cancer (3rd изд.). Abingdon: Radcliffe Medical Press.
- Hanks GW. Forbes K. Opioid responsiveness. Acta Anaesthesiologica Scandinavica. 1999; 41: 154–8.
- Cancer Pain Relief and Palliative Care. Geneva : WHO, 1990.
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