Piklozotan
Piklozotan (SUN-N4057) je selektivni parcijalni agonist 5-HT1A receptora, koji ima neuroprotektivno dejstvo u životinjskim studijama.[1] On je bio u ranim kliničkim ispitivanjima za tretman akutnog moždanog udara.[2][3]
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| IUPAC ime | |
|---|---|
3-hloro-4-[4-[4-(2-piridinil)-1,2,3,6-tetrahidropiridin-1-il]butil]-1,4-benzoksazepin-5(4H)-on | |
| Pravni status | |
| Pravni status |
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| Identifikatori | |
| CAS broj | 182415-09-4  |
| ATC kod | none |
| PubChem | CID 9801640 |
| UNII | FQE44HS7AH |
| Hemijski podaci | |
| Formula | C23H24ClN3O2 |
| Molarna masa | 409,909 g/mol |
| |
Reference уреди
- ^ Kamei, K.; Maeda, N.; Nomura, K.; Shibata, M.; Katsuragi-Ogino, R.; Koyama, M.; Nakajima, M.; Inoue, T.; Ohno, T. (2006). „Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan.”. Bioorganic & Medicinal Chemistry. 14 (6): 1978—1992. PMID 16290165. doi:10.1016/j.bmc.2005.10.046.
- ^ Ferro, J.; Dávalos, A. (2006). „Other neuroprotective therapies on trial in acute stroke”. Cerebrovascular diseases (Basel, Switzerland). 21 Suppl 2 (2): 127—130. PMID 16651823. doi:10.1159/000091712.
- ^ Mondick, J.; Oo, C.; Patel, D.; Fujitani, T.; Shimizu, K.; Barrett, J. (2009). „Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan”. American journal of therapeutics. 16 (2): 106—115. PMID 19300037. doi:10.1097/MJT.0b013e31816b8c85.}
