Pirolohinolin hinon
Pirolohinolin hinon (PQQ) je redoks kofaktor kod bakterija .[4][5][6][7] PQQ je prostetička grupa u metanolnoj dehidrogenazi metilotrofa, kao što je bakterijska vrsta Acetobacter.[8]
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| Identifikacija | |
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3D model (Jmol)
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| ChEBI | |
| ChemSpider | |
| KEGG[1] | |
| MeSH | PQQ+Cofactor |
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| Svojstva | |
| C14H6N2O8 | |
| Molarna masa | 330,21 g·mol−1 |
| Gustina | 1,963 g/cm3 |
| Opasnosti | |
| Tačka paljenja | 569,8 °C |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
Enzimi koji sadrže PQQ se nazivaju hinoproteini. Glukozna dehidrogenaza, jedan od hinoproteina, se koristi kao glukozni senzor. Utvrđeno je da PQQ stimuliše rast bakterija.[9] Osim toga, on ima antioksidansno i neuroprotektivno dejstvo.[10]
PQQ biosinteza kod bakterija počinje sa proteinskom biosintezom kojom se formira kratki peptid, PqqA, na ribozomu. Svi atomi u PQQ su izvedeni iz glutaminske kiseline i tirozina u PqqA, koji se povezuju posrestvom radikalnog SAM enzima PqqE.[11]
Reference уреди
- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Hauge JG (1964). „Glucose dehydrogenase of bacterium anitratum: an enzyme with a novel prosthetic group”. J Biol Chem. 239: 3630—9. PMID 14257587.
- ^ Anthony C, Zatman LJ (1967). „The microbial oxidation of methanol. The prosthetic group of the alcohol dehydrogenase of Pseudomonas sp. M27: a new oxidoreductase prosthetic group”. Biochem J. 104 (3): 960—9. PMC 1271238
. PMID 6049934.
- ^ Salisbury SA, Forrest HS, Cruse WB, Kennard O (1979). „A novel coenzyme from bacterial primary alcohol dehydrogenases”. Nature. 280 (5725): 843—4. PMID 471057. doi:10.1038/280843a0.
- ^ Westerling J, Frank J, Duine JA (1979). „The prosthetic group of methanol dehydrogenase from Hyphomicrobium X: electron spin resonance evidence for a quinone structure”. Biochem Biophys Res Commun. 87 (3): 719—24. PMID 222269. doi:10.1016/0006-291X(79)92018-7.
- ^ Ameyama M, Matsushita K, Ohno Y, Shinagawa E, Adachi O (1981). „Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria”. FEBS Lett. 130 (2): 179—83. PMID 6793395. doi:10.1016/0014-5793(81)81114-3.
- ^ Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). „Pyrroloquinoline quinone: excretion by methylotrophs and growth stimulation for microorganisms”. BioFactors. 1 (1): 51—3. PMID 2855583.
- ^ Rucker R, Chowanadisai W, Nakano M (2009). „Potential physiological importance of pyrroloquinoline quinone”. Altern Med Rev. 14 (3): 179—83.
- ^ Puehringer S, Metlitzky M, Schwarzenbacher R (2008). „The pyrroloquinoline quinone biosynthesis pathway revisited: a structural approach.”. BMC Biochem. 9: 8. PMID 18371220.
