Proklavaminatna amidinohidrolaza
Proklavaminatna amidinohidrolaza (EC 3.5.3.22, PAH, proklavaminatna amidino hidrolaza) je enzim sa sistematskim imenom amidinoproklavaminat amidinohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Proklavaminatna amidinohidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.3.22 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- amidinoproklavaminat + H2O proklavaminat + ureja
Ovaj enzim učestvuje u biositezi beta-laktamaznog inhibitora klavulanata u Streptomyces clavuligerus.
Reference уреди
- ^ Salowe, S.P., Krol, W.J., Iwatareuyl, D. and Townsend, C.A. (1991). „Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction”. Biochemistry. 30: 2281—2292. PMID 1998687.
- ^ Zhou, J., Kelly, W.L., Bachmann, B.O., Gunsior, M., Townsend, C.A. and Solomon, E.I. (2001). „Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities”. J. Am. Chem. Soc. 123: 7388—7398. PMID 11472170.
- ^ Townsend, C.A. (2002). „New reactions in clavulanic acid biosynthesis”. Curr. Opin. Chem. Biol. 6: 583—589. PMID 12413541.
- ^ Wu, T.K., Busby, R.W., Houston, T.A., McIlwaine, D.B., Egan, L.A. and Townsend, C.A. (1995). „Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis”. J. Bacteriol. 177: 3714—3720. PMID 7601835.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Proclavaminate+amidinohydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
