Ranibizumab (prodajno ime Lucentis) fragment je monoklonalnog antitela (Fab) izveden iz istog mišjeg antitela kao i bevacizumab (Avastin). On je znatno manji od roditeljskog molekula i bio je podvrgnut procesu maturacije afiniteta da bi se pojačalo vezivanje za VEGF-A. On je inhibitor angiogeneze koji je odobren za lečenje "vlažnog" tipa starostne makularne degeneracije (AMD, ARMD), i uobičajeme forme starosnog gubitka vida.[1][2][3][4][5][6][7][8]

Ranibizumab
Klinički podaci
Drugs.comMonografija
Način primeneIntravitrealno
Farmakokinetički podaci
Poluvreme eliminacije9 dana
Identifikatori
CAS broj347396-82-1 ДаY
ATC kodS01LA04 (WHO)
DrugBankDB01270 ДаY
UNIIZL1R02VT79 ДаY
KEGGD05697 ДаY
ChEMBLCHEMBL1201825 ДаY
Hemijski podaci
FormulaC2158H3282N562O681S12
Molarna masa48000

ReferenceУреди

  1. ^ IGMT Link:http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1CZ8&Part=Chain Архивирано на сајту Wayback Machine (7. децембар 2008)
  2. ^ Gaudreault J, Fei D, Beyer JC, Ryan A, Rangell L, Shiu V, Damico LA: Pharmacokinetics and retinal distribution of ranibizumab, a humanized antibody fragment directed against VEGF-A, following intravitreal administration in rabbits. Retina. 2007 Nov-Dec;27(9):1260-6. PMID 18046235
  3. ^ Gaudreault J, Fei D, Rusit J, Suboc P, Shiu V: Preclinical pharmacokinetics of Ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):726-33. PMID 15671306
  4. ^ Gaudreault J, Fei D, Beyer JC, Ryan A, Rangell L, Shiu V, Damico LA: Pharmacokinetics and retinal distribution of ranibizumab, a humanized antibody fragment directed against VEGF-A, following intravitreal administration in rabbits. Retina. 2007 Nov-Dec;27(9):1260-6. PMID 18046235
  5. ^ Bakri SJ, Snyder MR, Reid JM, Pulido JS, Ezzat MK, Singh RJ: Pharmacokinetics of intravitreal ranibizumab (Lucentis). Ophthalmology. 2007 Dec;114(12):2179-82. PMID 18054637
  6. ^ Kourlas H, Abrams P: Ranibizumab for the treatment of neovascular age-related macular degeneration: a review. Clin Ther. 2007 Sep;29(9):1850-61. PMID 18035187
  7. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  8. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди

LiteraturaУреди

Spoljašnje vezeУреди

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