Temokapril
Temokapril (Temokaprilum, Acecol) je ACE inhibitor.[1] On nije odobren za upotrebu u SAD.
 | |
| IUPAC ime | |
|---|---|
[(2S)-6[(1S)-1-(etoksikarbonil)-3-fenilpropil]amino5-okso-2-(2-tienil)-1,4-tiazepan-4-il]sirćetna kiselina | |
| Klinički podaci | |
| Drugs.com | Internacionalno ime leka |
| Identifikatori | |
| CAS broj | 111902-57-9 |
| ATC kod | C09AA14 (WHO) |
| PubChem | CID 71323 |
| UNII | 18IZ008EU6  |
| KEGG | D08566 |
| Hemijski podaci | |
| Formula | C23H28N2O5S2 |
| Molarna masa | 476,608 g/mol |
Osobine уреди
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 7 |
| Broj donora vodonika | 2 |
| Broj rotacionih veza | 11 |
| Particioni koeficijent[2] (ALogP) | 0,8 |
| Rastvorljivost[3] (logS, log(mol/L)) | -5,6 |
| Polarna površina[4] (PSA, Å2) | 149,5 |
Reference уреди
- ^ Hisao Oguchi1, Masuo Tokoo, Shinichi Tokunaga, Makoto Higuchi, Kazuhiko Hora, Seiichi Furuta (1995). „Temocapril, A Novel Angiotensin-Converting Enzyme Inhibitor with Preferential Biliary Excretion”. 13: 66—85. doi:10.1111/j.1527-3466.1995.tb00214.x.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura уреди
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze уреди
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
