Tesamorelin (Egrifta) je sintetička forma hormona faktora rasta koji se koristi u lečenju lipodistrofije vezane za HIV. Tesamorelin je razvilo preduzeće Theratechnologies, Inc. of Canada.[1][2][3][4][5][6][7][8][9]

Tesamorelin
Klinički podaci
Drugs.comMonografija
Način primeneSubkutano
Farmakokinetički podaci
Poluvreme eliminacije26 - 38 minuta
Identifikatori
CAS broj901758-09-6 ДаY
ATC kodH01AC06 (WHO)
DrugBankDB08869 ДаY
ChEBICHEBI:63626 ДаY
Hemijski podaci
FormulaC221H366N72O67S
Molarna masa5135.86

ReferenceУреди

  1. ^ Spooner LM, Olin JL: Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy. Ann Pharmacother. 2012 Feb;46(2):240-7. doi: 10.1345/aph.1Q629. Epub 2012 Jan 31. PMID 22298602
  2. ^ McLarnon A: Neuroendocrinology: Tesamorelin can improve cognitive function. Nat Rev Endocrinol. 2012 Oct;8(10):568. doi: 10.1038/nrendo.2012.151. Epub 2012 Aug 28. PMID 22926095
  3. ^ Bedimo R: Growth hormone and tesamorelin in the management of HIV-associated lipodystrophy. HIV AIDS (Auckl). 2011;3:69-79. doi: 10.2147/HIV.S14561. Epub 2011 Jul 10. PMID 22096409
  4. ^ Dhillon S: Spotlight on tesamorelin in HIV-associated lipodystrophy. BioDrugs. 2011 Dec 1;25(6):405-8. doi: 10.2165/11208290-000000000-00000. PMID 22050344
  5. ^ Garg A: Acquired and inherited lipodystrophies. N Engl J Med. 2004 Mar 18;350(12):1220-34. PMID 15028826
  6. ^ Patel A, Gandhi H, Upaganlawar A: Tesamorelin: A hope for ART-induced lipodystrophy. J Pharm Bioallied Sci. 2011 Apr;3(2):319-20. doi: 10.4103/0975-7406.80763. PMID 21687371
  7. ^ Campbell RM, Lee Y, Rivier J, Heimer EP, Felix AM, Mowles TF: GRF analogs and fragments: correlation between receptor binding, activity and structure. Peptides. 1991 May-Jun;12(3):569-74. PMID 1656403
  8. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  9. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди

LiteraturaУреди

Spoljašnje vezeУреди

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