Ergokalciferol

Ergokalciferol
Nazivi
	IUPAC naziv (3β,5Z,7E,22E)-9,10-sekoergosta-5,7,10(19),22-tetraen-3-ol
	Drugi nazivi Drisdol, Calcidol
Identifikacija
CAS broj	50-14-6 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:28934 ;
ChemSpider	4444351 ;
DrugBank	DB00153 ;
ECHA InfoCard	100.000.014
KEGG	C05441 ;
PubChem C ID	5280793;
UNII	VS041H42XC ;
	SMILES O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](/C=C/[C@H](C)C(C)C)C)C; ; ; ; ; ;
Svojstva
Hemijska formula	C28H44O
Molarna masa	396,65 g/mol
Tačka topljenja	114–118 °C
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Ergokalciferol je forma vitamina D, poznata kao vitamin D₂. On je u prodaji pod raznim imenima uključujući: Deltalin, Drisdol, i Calcidol. Formira se iz viosterola kad ultraljubičasto svetlo aktivira ergosterol. Gljive su primarni prirodni izvor.

Ergokalciferol se može koristiti kao suplement vitamina D. Jedna klinička smernica iz 2011.^[4] ga smatra jednako efektivnim kao i holekalciferol (vitamin D₃), koji prirodno proizvodi koža pri izlaganju ultraljubičastom svetlu. Postoji konfliktna evidencija o tome u kojoj meri D₂ i D₃ imaju slično dejstvo u telu i da li su jednako aktivni. Neke studije sugerišu da je D₃ potentniji,^[5]^[6] dok druge iznose jednaku potentnost.^[4]^[7]^[8]

Uloga u Alchajmerovoj bolesti уреди

Jedna nedavna studija je utvrdila da veoma niske nivoe vitamina D₂ kod pacijenata obolelih od Alchajmerove bolesti.^[9]

Reference уреди

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ ^а ^б Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). „Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. Journal of Clinical Endocrinology & Metabolism. 96 (7): 1911. PMID 21646368. doi:10.1210/jc.2011-0385.
^ Houghton, L.; Vieth, R. (2006). „The case against ergocalciferol (vitamin D2) as a vitamin supplement”. The American Journal of Clinical Nutrition. 84 (4): 694—697. PMID 17023693.
^ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). „Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2”. The American journal of clinical nutrition. 68 (4): 854—858. PMID 9771862.
^ Holick Mf, B. R.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W.; Ameri, A. (2007). „Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D”. Journal of Clinical Endocrinology & Metabolism. 93 (3): 677—681. PMC 2266966  . PMID 18089691. doi:10.1210/jc.2007-2308.
^ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R.; Salameh, W. (2010). „Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults”. American Journal of Clinical Nutrition. 91 (6): 1621—1626. PMC 2869510  . PMID 20427729. doi:10.3945/ajcn.2009.27972.
^ Shah, Iltaf; Petroczi, Andrea; Tabet, Naji; Klugman, Anthony; Isaac, Mokhtar; p. Naughton, Declan (2012). „Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls”. Current Alzheimer Research. 9 (9): 1069—1076. ISSN 1567-2050. doi:10.2174/156720512803568975.

Spoljašnje veze уреди

NIST Chemistry WebBook page for ergocalciferol

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[holick_guideline-4] а ^б Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). „Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. Journal of Clinical Endocrinology & Metabolism. 96 (7): 1911. PMID 21646368. doi:10.1210/jc.2011-0385.

[the_case_against_ergocalciferol-5] Houghton, L.; Vieth, R. (2006). „The case against ergocalciferol (vitamin D2) as a vitamin supplement”. The American Journal of Clinical Nutrition. 84 (4): 694—697. PMID 17023693.

[trang-6] Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). „Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2”. The American journal of clinical nutrition. 68 (4): 854—858. PMID 9771862.

[holick-as_effective-7] Holick Mf, B. R.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W.; Ameri, A. (2007). „Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D”. Journal of Clinical Endocrinology & Metabolism. 93 (3): 677—681. PMC 2266966  . PMID 18089691. doi:10.1210/jc.2007-2308.

[orange_juice-8] Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R.; Salameh, W. (2010). „Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults”. American Journal of Clinical Nutrition. 91 (6): 1621—1626. PMC 2869510  . PMID 20427729. doi:10.3945/ajcn.2009.27972.

[9] Shah, Iltaf; Petroczi, Andrea; Tabet, Naji; Klugman, Anthony; Isaac, Mokhtar; p. Naughton, Declan (2012). „Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls”. Current Alzheimer Research. 9 (9): 1069—1076. ISSN 1567-2050. doi:10.2174/156720512803568975.

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