Volinanserin
Volinanserin (MDL-100,907) je visoko selektivan antagonist 5-HT2A receptor. On je u širokoj upotrebi u naučnim istraživanjima za istraživanje funkcije 5-HT2A receptora.[1][2][3] Volinanserin se isto tako ispituje kao potencijalni antipsihotik, antidepresiv i tretman za insomniju.[4][5][6]
 | |
| IUPAC ime | |
|---|---|
(R)-(2,3-dimetoksifenil)-[1-[2-(4-fluorofenil)etil]-4-piperidil]metanol | |
| Identifikatori | |
| CAS broj | 139290-65-6  |
| ATC kod | none |
| PubChem | CID 5311271 |
| IUPHAR/BPS | 185 |
| ChemSpider | 4470782 |
| UNII | EW71EE171J |
| ChEMBL | CHEMBL74355 |
| Hemijski podaci | |
| Formula | C22H28FNO3 |
| Molarna masa | 373,46 g/mol |
| |
Reference уреди
- ^ Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL (1992). „5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine”. European Journal of Pharmacology. 223 (1): 65—74. PMID 1362159. doi:10.1016/0014-2999(92)90819-P.
- ^ Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F (2009). „Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET”. Bioorganic & Medicinal Chemistry. 17 (8): 2989—3002. PMID 19329329. doi:10.1016/j.bmc.2009.03.021.
- ^ Nic Dhonnchadha BA, Fox RG, Stutz SJ, Rice KC, Cunningham KA (2009). „Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model”. Behavioral Neuroscience. 123 (2): 382—96. PMID 19331461. doi:10.1037/a0014592.
- ^ Offord SJ, Wong DF, Nyberg S (1999). „The role of positron emission tomography in the drug development of M100907, a putative antipsychotic with a novel mechanism of action”. Journal of Clinical Pharmacology. Suppl: 17S—24S. PMID 10434243.
- ^ Marek GJ, Martin-Ruiz R, Abo A, Artigas F (2005). „The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine”. Neuropsychopharmacology. 30 (12): 2205—15. PMID 15886717. doi:10.1038/sj.npp.1300762.
- ^ Teegarden BR, Al Shamma H, Xiong Y (2008). „5-HT(2A) inverse-agonists for the treatment of insomnia”. Current Topics in Medicinal Chemistry. 8 (11): 969—76. PMID 18673166. doi:10.2174/156802608784936700.
