Отворите главни мени

XRCC1 je protein popravke DNK. On formira kompleks sa DNK ligazom III.

XRCC1
PDB prikaz baziran na 1cdz.
Dostupne strukture
1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 3LQC
Identifikatori
Simboli XRCC1; RCC
Vanjski ID OMIM194360 MGI99137 HomoloGene31368 GeneCards: XRCC1 Gene
Pregled RNK izražavanja
PBB GE XRCC1 203655 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 7515 22594
Ensembl ENSG00000073050 ENSMUSG00000051768
UniProt P18887 Q60596
RefSeq (mRNA) NM_006297.2 NM_009532.4
RefSeq (protein) NP_006288.2 NP_033558.3
Lokacija (UCSC) Chr 19:
44.05 - 44.08 Mb
Chr 7:
25.33 - 25.36 Mb
PubMed pretraga [1] [2]

Ovaj protein učestvuje u popravci jednolančankih prekida DNK formiranih izlaganjem jonizujućoj radijaciji i alkilujućim agensima. Ovaj protein formira interakcije sa DNK ligazom III, polimerazom beta i poli ADP-riboznom polimerazom da bi učestvovao u putu popravke isecanjem baza. Moguće je da ima ulogu u DNK manipulacijama tokom mejoze i rekombinacije u ćelijama zametka. Retki mikrosatelitni polimorfizam ovog genu je vezan za pojavu pojedinih tipova kancera.[1]

InterakcijeУреди

ReferenceУреди

  1. ^ „Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1”. 
  2. ^ Schreiber, Valérie; et al. (2002). „Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1”. J. Biol. Chem. United States. 277 (25): 23028—36. ISSN 0021-9258. PMID 11948190. doi:10.1074/jbc.M202390200. 
  3. ^ Wang, Liming; et al. (2004). „A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype”. Cancer Res. United States. 64 (21): 7673—7. ISSN 0008-5472. PMID 15520167. doi:10.1158/0008-5472.CAN-04-2801. 
  4. 4,0 4,1 Fan, Jinshui; et al. (2004). „XRCC1 co-localizes and physically interacts with PCNA”. Nucleic Acids Res. England. 32 (7): 2193—201. PMC 407833 . PMID 15107487. doi:10.1093/nar/gkh556. 
  5. ^ Kubota, Y; et al. (1996). „Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein”. EMBO J. ENGLAND. 15 (23): 6662—70. ISSN 0261-4189. PMC 452490 . PMID 8978692. 
  6. ^ Bhattacharyya, N; S, Banerjee (2001). „A novel role of XRCC1 in the functions of a DNA polymerase beta variant”. Biochemistry. United States. 40 (30): 9005—13. ISSN 0006-2960. PMID 11467963. doi:10.1021/bi0028789. 
  7. ^ Date, Hidetoshi; et al. (2004). „The FHA domain of aprataxin interacts with the C-terminal region of XRCC1”. Biochem. Biophys. Res. Commun. United States. 325 (4): 1279—85. ISSN 0006-291X. PMID 15555565. doi:10.1016/j.bbrc.2004.10.162. 
  8. 8,0 8,1 Gueven, Nuri; et al. (2004). „Aprataxin, a novel protein that protects against genotoxic stress”. Hum. Mol. Genet. England. 13 (10): 1081—93. ISSN 0964-6906. PMID 15044383. doi:10.1093/hmg/ddh122. 
  9. ^ Marsin, Stéphanie; et al. (2003). „Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1”. J. Biol. Chem. United States. 278 (45): 44068—74. ISSN 0021-9258. PMID 12933815. doi:10.1074/jbc.M306160200. 
  10. ^ Vidal, A E; et al. (2001). „XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions”. EMBO J. England. 20 (22): 6530—9. ISSN 0261-4189. PMC 125722 . PMID 11707423. doi:10.1093/emboj/20.22.6530. 
  11. ^ Whitehouse, C J; et al. (2001). „XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair”. Cell. United States. 104 (1): 107—17. ISSN 0092-8674. PMID 11163244. doi:10.1016/S0092-8674(01)00195-7. 
  12. ^ Ewing, Rob M; et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. England. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134. 
  13. ^ Masson, M; et al. (1998). „XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage”. Mol. Cell. Biol. UNITED STATES. 18 (6): 3563—71. ISSN 0270-7306. PMC 108937 . PMID 9584196. 

LiteraturaУреди

Spoljašnje vezeУреди