Dženel Ers
Dženel Ers (engl. Janelle S. Ayres) je američka imunologinja i mikrobiologinja, članica NOMIS-a Centra za imunobiologiju i patogenezu mikroba i predsedavajuća na Institutu za biološke nauke Salk (engl. Salk Institute for Biological Studies).[1] Njeno istraživanje usredsređeno je na odnose u interakcije domaćin-patogen sa mikrobiomom.[2]
| Dženel Ers | |
|---|---|
 | |
| Lični podaci | |
| Prebivalište | SAD |
| Naučni rad | |
| Polje | mikrobiologija, imunologija |
| Institucija | Univerzitet Kalifornije (Berkli) |
| Poznat po | izučavanju kako mikrobi mogu da promovišu zdravlje u organizmu svog domaćina |
Obrazovanje uredi
Diplomirala je molekularnu i ćelijsku biologiju na Univerzitet Kalifornije (Berkli) a doktorirala na Medicinskom fakultetu Univerziteta Stanford u laboratoriji Davida Schneidera, radeći na izučavanju otpornosti i toleranciji mikroorganizama na infekciju primenom modela, organizma vinske mušice (Drosophila).[3][4] Zatim je završila postdoktorske studije sa Russell Vance na Univerzitet Kalifornije (Berkli), gde je obavila istraživanja o ulozi urođenog imuniteta u prepoznavanju patobionata otpornih na lekove ili potencijalno virulentnih vrsta iz mikrobioma.[5]
Istraživanja uredi
Trenutno istraživanje Dženel Ers fokusira se na to kako mikrobi mogu da promovišu zdravlje u organizmu svog domaćina. U tom istraživanju ona koristi matematičke i evolucione modele da predvidi kako se korisni mikrobi u crevima mogu primeniti za borbu protiv bolesti. Konkretno, njena laboratorija je pokazala kako soj Ešerihije koli sprečava oštećenja izazvan upalom i kako soj Salmonele inhibira anoreksiju izazvanu bolešću, štiteći tako svog domaćina od štetnih efekata infekcije.[6][7]
Bibliografija uredi
- Troha, Katia; Ayres, Janelle S. (2020). „Metabolic Adaptations to Infections at the Organismal Level”. Trends in Immunology. 41 (2): 113—125. PMC 7409656
. PMID 31959515. doi:10.1016/j.it.2019.12.001. - Ayres, Janelle S. (2020). „Immunometabolism of infections”. Nature Reviews Immunology. 20 (2): 79—80. PMID 31892735. S2CID 256745976. doi:10.1038/s41577-019-0266-9.
- McCarville, Justin L.; Ayres, Janelle S. (2019). „Host-Pathogen Relationship Advice: Fat Protects against a Broken Heart”. Cell Metabolism. 30 (3): 409—411. PMID 31484052. S2CID 201837574. doi:10.1016/j.cmet.2019.08.007.
- Wallace, Martina; Green, Courtney R.; Roberts, Lindsay S.; Lee, Yujung Michelle; McCarville, Justin L.; Sanchez-Gurmaches, Joan; Meurs, Noah; Gengatharan, Jivani M.; Hover, Justin D.; Phillips, Susan A.; Ciaraldi, Theodore P.; Guertin, David A.; Cabrales, Pedro; Ayres, Janelle S.; Nomura, Daniel K.; Loomba, Rohit; Metallo, Christian M. (2018). „Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues”. Nature Chemical Biology. 14 (11): 1021—1031. PMC 6245668 . PMID 30327559. doi:10.1038/s41589-018-0132-2.
- Sanchez, Karina K.; Chen, Grischa Y.; Schieber, Alexandria M. Palaferri; Redford, Samuel E.; Shokhirev, Maxim N.; Leblanc, Mathias; Lee, Yujung M.; Ayres, Janelle S. (2018). „Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen”. Cell. 175 (1): 146—158.e15. PMC 6447043 . PMID 30100182. doi:10.1016/j.cell.2018.07.016.
- Chen, G.Y., Ayres, J.S. When the Gut Gets Tough, the Enterocytes Get Going. (2018) Immunity. . Chen, Grischa Y.; Ayres, Janelle S. (2018). „When the Gut Gets Tough, the Enterocytes Get Going”. Immunity. 48 (5): 837—839. PMID 29768167. doi:10.1016/j.immuni.2018.04.036.
- McCarville, J.L., Ayres, J.S. Disease tolerance: concept and mechanisms. (2018) Current Opinion in Immunology. McCarville, JL; Ayres, JS (2018). „Disease tolerance: Concept and mechanisms”. Current Opinion in Immunology. 50: 88—93. PMC 5884632 . PMID 29253642. doi:10.1016/j.coi.2017.12.003.
- Lee, Y.M., Ayres, J.S. Decoding the intestinal epithelium cell by cell. (2018) Nature Immunology. . Lee, Yujung Michelle; Ayres, Janelle S. (2018). „Decoding the intestinal epithelium cell by cell”. Nature Immunology. 19 (1): 7—9. PMID 29242547. S2CID 256821060. doi:10.1038/s41590-017-0011-0.
- Rao, S., Ayres, J.S. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. (2017) Seminars in Immunology. Rao, Sheila; Ayres, Janelle S. (2017). „Resistance and tolerance defenses in cancer: Lessons from infectious diseases”. Seminars in Immunology. 32: 54—61. PMID 28865876. doi:10.1016/j.smim.2017.08.004.
- Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. (2017) Immunity. . Rauch, Isabella; Deets, Katherine A.; Ji, Daisy X.; von Moltke, Jakob; Tenthorey, Jeannette L.; Lee, Angus Y.; Philip, Naomi H.; Ayres, Janelle S.; Brodsky, Igor E.; Gronert, Karsten; Vance, Russell E. (2017). „NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8”. Immunity. 46 (4): 649—659. PMC 5476318 . PMID 28410991. doi:10.1016/j.immuni.2017.03.016.
- Rao, Sheila; Schieber, Alexandria M. Palaferri; o'Connor, Carolyn P.; Leblanc, Mathias; Michel, Daniela; Ayres, Janelle S. (2017). „Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission”. Cell. 168 (3): 503—516.e12. PMC 5324724 . PMID 28129542. doi:10.1016/j.cell.2017.01.006.
- Ayres, J.S. Microbes Dress for Success: Tolerance or Resistance? (2017) Trends in Microbiology. . Ayres, Janelle S. (2017). „Microbes Dress for Success: Tolerance or Resistance?”. Trends in Microbiology. 25 (1): 1—3. PMID 27894645. doi:10.1016/j.tim.2016.11.006.
- Schieber, Alexandria M. Palaferri; Ayres, Janelle S. (2016). „Thermoregulation as a disease tolerance defense strategy”. Pathogens and Disease. 74 (9): ftw106. PMC 5975229 . PMID 27815313. doi:10.1093/femspd/ftw106.
- Ayres, J.S. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. (2016) Cell. . Ayres, Janelle S. (2016). „Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat”. Cell. 166 (6): 1368—1370. PMID 27610563. S2CID 6553558. doi:10.1016/j.cell.2016.08.034.
- Ayres, J.S. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. (2016) Cell. . Ayres, Janelle S. (2016). „Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism”. Cell. 165 (6): 1323—1331. PMC 4903080 . PMID 27259146. doi:10.1016/j.cell.2016.05.049.
- Shen, Run; Wang, Biao; Giribaldi, Maria G.; Ayres, Janelle; Thomas, John B.; Montminy, Marc (2016). „Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance”. Proceedings of the National Academy of Sciences. 113 (23): E3307—14. PMC 4988575 . PMID 27208092. doi:10.1073/pnas.1606106113 .
- Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) Science. . Schieber, Alexandria M. Palaferri; Lee, Yujung Michelle; Chang, Max W.; Leblanc, Mathias; Collins, Brett; Downes, Michael; Evans, Ronald M.; Ayres, Janelle S. (2015). „Disease tolerance mediated by microbiome E. Coli involves inflammasome and IGF-1 signaling”. Science. 350 (6260): 558—563. PMC 4732872 . PMID 26516283. doi:10.1126/science.aac6468.
- Ayres, J.S. Inflammasome-microbiota interplay in host physiologies. (2013) Cell Host & Microbe. . Ayres, Janelle S. (2013). „Inflammasome-Microbiota Interplay in Host Physiologies”. Cell Host & Microbe. 14 (5): 491—497. PMID 24237695. doi:10.1016/j.chom.2013.10.013.
- Manzanillo, P.S., Ayres, J.S., Watson, R.O., Collins, A.C., Souza, G., Rae, C.S., Schneider, D.S., Nakamura, K., Shiloh, M.U., Cox, J.S. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. (2013) Nature. . Manzanillo, Paolo S.; Ayres, Janelle S.; Watson, Robert O.; Collins, Angela C.; Souza, Gianne; Rae, Chris S.; Schneider, David S.; Nakamura, Ken; Shiloh, Michael U.; Cox, Jeffery S. (2013). „The ubiquitin ligase parkin mediates resistance to intracellular pathogens”. Nature. 501 (7468): 512—516. PMC 3886920 . PMID 24005326. doi:10.1038/nature12566.
- von Moltke, J., Ayres, J.S., Kofoed, E.M., Chavarría-Smith, J., Vance, R.E. Recognition of bacteria by inflammasomes. (2013) Annual Review of Immunology. von Moltke, Jakob; Ayres, Janelle S.; Kofoed, Eric M.; Chavarría-Smith, Joseph; Vance, Russell E. (2013). „Recognition of Bacteria by Inflammasomes”. Annual Review of Immunology. 31: 73—106. PMID 23215645. doi:10.1146/annurev-immunol-032712-095944.
- Ayres, J.S., Trinidad, N.J., Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. (2012) Nature Medicine. . Ayres, Janelle S.; Trinidad, Norver J.; Vance, Russell E. (2012). „Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota”. Nature Medicine. 18 (5): 799—806. PMC 3472005 . PMID 22522562. doi:10.1038/nm.2729.
- Ayres, J.S., Vance, R.E. Cellular teamwork in antibacterial innate immunity. (2012) Nature Immunology. . Ayres, Janelle S.; Vance, Russell E. (2012). „Cellular teamwork in antibacterial innate immunity”. Nature Immunology. 13 (2): 115—117. PMID 22261960. S2CID 6819792. doi:10.1038/ni.2212.[8]
Izvori uredi
- ^ „Janelle Ayres | Blavatnik Awards for Young Scientists”. blavatnikawards.org. Pristupljeno 7. 3. 2021.
- ^ „Janelle Ayres”. Salk Institute for Biological Studies (na jeziku: engleski). Pristupljeno 7. 3. 2021.
- ^ Ayres, Janelle S.; Schneider, David S. (jul 2009). „The role of anorexia in resistance and tolerance to infections in Drosophila”. PLOS Biology. 7 (7): e1000150. ISSN 1545-7885. PMC 2701602 . PMID 19597539. doi:10.1371/journal.pbio.1000150 .
- ^ Ayres, Janelle S.; Schneider, David S. (2008-12-09). „A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections”. PLOS Biology. 6 (12): 2764—2773. ISSN 1545-7885. PMC 2596860 . PMID 19071960. doi:10.1371/journal.pbio.0060305 .
- ^ Ayres, J. S.; Trinidad, N. J.; Vance, R. E. (2012). „Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota”. Nature Medicine. 18 (5): 799—806. PMC 3472005 . PMID 22522562. doi:10.1038/nm.2729.
- ^ Palaferri Schieber, Alexandria M.; Lee, Yujung Michelle; Chang, Max W.; Leblanc, Mathias; Collins, Brett; Downes, Michael; Evans, Ronald M.; Ayres, Janelle S. (2015-10-30). „Disease tolerance mediated by commensal E. coli via inflammasome and IGF-1 signaling”. Science. 350 (6260): 558—563. ISSN 0036-8075. PMC 4732872 . PMID 26516283. doi:10.1126/science.aac6468.
- ^ Rao, Sheila; Schieber, Alexandria M. Palaferri; O'Connor, Carolyn P.; Leblanc, Mathias; Michel, Daniela; Ayres, Janelle S. (26. 1. 2017). „Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission”. Cell. 168 (3): 503—516.e12. ISSN 1097-4172. PMC 5324724 . PMID 28129542. doi:10.1016/j.cell.2017.01.006.
- ^ „Publications”. Salk Institute for Biological Studies (na jeziku: engleski). Pristupljeno 2020-03-14.
Spoljašnje veze uredi
Mediji vezani za članak Dženel Ers na Vikimedijinoj ostavi