AMN082
AMN082 (N,N'-dibenzhidriletan-1,2-diamin dihidrohlorid) je selektivni alosterni agonist metabotropnog glutamatnog receptora 7 (mGluR7).[3][4] On oponaša dejstvo glutamata. AMN082 je prvi selektivni mGluR7 agonist.
Nazivi | |
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IUPAC naziv
N,N'-dibenzhidriletan-1,2-diamin dihidrohlorid
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Identifikacija | |
3D model (Jmol)
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ChemSpider | |
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Svojstva | |
C28H30Cl2N2 | |
Molarna masa | 465,4572 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
verifikuj (šta je ?) | |
Reference infokutije | |
Reference уреди
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Li X, Gardner EL, Xi ZX (2008). „The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats”. Neuropharmacology. 54 (3): 542—51. PMC 2410088 . PMID 18155073. doi:10.1016/j.neuropharm.2007.11.005.
- ^ Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). „Activation of the mGlu7 receptor elicits antidepressant-like effects in mice”. Psychopharmacology (Berl.). 194 (4): 555—62. PMID 17622518. doi:10.1007/s00213-007-0856-2.