Dolihil-P-Glc:Man9GlcNAc2-PP-dolihol alfa-1,3-glukoziltransferaza

Dolihil-P-Glc:Man9GlcNAc2-PP-dolihol alfa-1,3-glukoziltransferaza (EC 2.4.1.267, ALG6, Dol-P-Glc:Man9GlcNAc2-PP-Dol alfa-1,3-glukoziltransferaza) je enzim sa sistematskim imenom dolihil beta-D-glukozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->2)-D-Man-alfa-(1->6))-D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-1,3-glukoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Dolihil-P-Glc:Man9GlcNAc2-PP-dolihol alfa-1,3-glukoziltransferaza
Identifikatori
EC broj2.4.1.267
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
dolihil beta-D-glukozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol D-Glc-alfa-(1->3)-D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + dolihil fosfat

Konsekutivna adicija tri glukozna ostatka posredstvom enzima EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alfa-1,3-glukoziltransferaza) i EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alfa-1,2-glukoziltransferaza) predstavlja finalni korak formiranja lipid-vezanog oligosaharidnog sklopa.

Reference

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  1. ^ Reiss, G., te Heesen, S., Zimmerman, J., Robbins, P.W. and Aebi, M. (1996). „Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway”. Glycobiology. 6: 493—498. PMID 8877369. 
  2. ^ Runge, K.W., Huffaker, T.C. and Robbins, P.W. (1984). „Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway”. J. Biol. Chem. 259: 412—417. PMID 6423630. 
  3. ^ Westphal, V., Xiao, M., Kwok, P.Y. and Freeze, H.H. (2003). „Identification of a frequent variant in ALG6, the cause of congenital disorder of glycosylation-Ic”. Hum. Mutat. 22: 420—421. PMID 14517965. 

Literatura

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Spoljašnje veze

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