Dolihil-P-Man:Man6GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza

Dolihil-P-Man:Man6GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza (EC 2.4.1.259, ALG9, ALG9 alfa1,2 manoziltransferaza, dolihilfosfomanoza-zavisna ALG9 manoziltransferaza, ALG9 manoziltransferaza, Dol-P-Man:Man6GlcNAc2-PP-Dol alfa-1,2-manoziltransferaza) je enzim sa sistematskim imenom dolihil beta-D-manozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->3)-D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-1,2-manoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Dolihil-P-Man:Man6GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza
Identifikatori
EC broj2.4.1.259
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
dolihil beta-D-manozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + dolihil fosfat

Tokom formiranja N-glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih oligosaharida sa Glc3Man9GlcNAc2 osnovom na lipidnom nosiocu dolihil difosfatu.

Reference

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  1. ^ Vleugels, W., Keldermans, L., Jaeken, J., Butters, T.D., Michalski, J.C., Matthijs, G. and Foulquier, F. (2009). „Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient”. Glycobiology. 19: 910—917. PMID 19451548. 
  2. ^ Cipollo, J.F. & Trimble, R.B. (2000). „The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Δalg9 mutant reveals a regulatory role for the Alg3p α1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing”. J. Biol. Chem. 275: 4267—4277. PMID 10660594. 
  3. ^ Frank, C.G. & Aebi, M. (2005). „ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis”. Glycobiology. 15: 1156—1163. PMID 15987956. 

Literatura

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Spoljašnje veze

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