BZIP domen — разлика између измена

bZIP transkripcioni faktori su prisutni u svim organizmima. Jedna nedavna evoluciona studija je pokazala da su 4 bZIP gena bila kodirana u genomu [[najskoriji zajednički predak|najskorijeg zajedničkog pretka]] svih biljki.<ref name="pmid18698409 ">{{cite journal |author=Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. |title=The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes |journal=PLoS ONE |volume=3 |issue=8 |pages=e2944 |year=2008 |pmid=18698409 |doi=10.1371/journal.pone.0002944 |pmc=2492810 |editor1-last=Shiu |editor1-first=Shin-Han}}</ref> Interakcije između bZIP transkripcionih faktora imaju važnu ulogu u razvoju kancera<ref name="pmid18348191">{{cite journal |vauthors=Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V | title = The role of ATF-2 in oncogenesis | journal = BioEssays | volume = 30 | issue = 4 | pages = 314–27 | year = 2008 | month = April | pmid = 18348191 | doi = 10.1002/bies.20734 | url = }}</ref> u [[epitel]]nim tkivima, sintezi steroidnih hormona u ćelijama [[Ендокрини систем|endokrinih tkiva]],<ref name="pmid11773448">{{cite journal |vauthors=Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM | title = Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family | journal = Mol. Endocrinol. | volume = 16 | issue = 1 | pages = 184–99 | year = 2002 | month = January | pmid = 11773448 | doi = 10.1210/me.16.1.184| url = }}</ref> faktora koji utiču na reproduktivne funkcije,<ref name="pmid10218980">{{cite journal |vauthors=Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS | title = Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun | journal = Endocrinology | volume = 140 | issue = 5 | pages = 2268–79 | year = 1999 | month = May | pmid = 10218980 | doi = 10.1210/en.140.5.2268| url = }}</ref> i više drugih fenomena koji utiču na ljudsko zdravlje.