Oksibutinin — разлика између измена
Садржај обрисан Садржај додат
м corrected template |
didaktičke promjene strukturne formule / stereokemije |
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Ред 3:
| verifiedrevid = 462267372
| IUPAC_name = 4-Dietilaminobut-2-inil 2-cikloheksil-2-hidroksi-2-feniletanoat
| image = (RS)-Oxybutynin
| width = 250px
| image2 = Oxybutynin 3d balls.png
| width2 = 250px
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Ред 56:
Oksibutinin je takođe mogući tretman za [[Хиперхидроза|hiperhidrozu]], ili hiperaktivno znojenje.<ref>{{cite journal |vauthors=Tupker RA, Harmsze AM, Deneer VH | title = Oxybutynin therapy for generalized hyperhidrosis. | journal = Arch Dermatol | volume = 142| issue = 8 | pages = 1065–6| year = 2006 | pmid = 16924061 | doi = 10.1001/archderm.142.8.1065 }}</ref><ref>{{cite journal |vauthors=Mijnhout GS, Kloosterman H, Simsek S, Strack van Schijndel RJ, Netelenbos JC | title = Oxybutynin: dry days for patients with hyperhidrosis. | journal = Neth J Med | volume = 64 | issue = 9 | pages = 326–8| year = 2006 | pmid = 17057269 }}</ref><ref>{{cite journal |vauthors=Schollhammer M, Misery L | title = Treatment of hyperhidrosis with oxybutynin. | journal = Arch Dermatol. | volume = 143 | issue = 4 | pages = 544–5| year = 2007 | pmid = 17438194 | doi = 10.1001/archderm.143.4.544 }}</ref>
== Stereokemija ==
Oxybutynin sadrži stereocentar i sastoji se od dva enantiomera. Ovo je racemat, tj. 1: 1 smjesa (R) - i (S) -form:<ref>Kachur JF, et al. ''R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine'', ''[[Journal of Pharmacology and Experimental Therapeutics]]'', 247, S. 867–872, 1988; PMID 2849672.</ref><ref>Noronha-Blob L, Kachur JF. ''Enantiomers of oxybutynin: in vitro pharmacological characterization at M<sub>1</sub>, M<sub>2</sub> and M<sub>3</sub> muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs'', ''[[Journal of Pharmacology and Experimental Therapeutics]]'', 256, S. 562–567, 1991; PMID 1993995.</ref>
{| class="wikitable" style="text-align:center"
|- class="hintergrundfarbe6"
! colspan="2"| Enantiomeri oksibutinina
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| [[File:(R)-Oxybutynin Structural Formula V1.svg|250 px]]<br /><small> CAS-Nummer: 119618-21-2</small>
| [[File:(S)-Oxybutynin Structural Formula V1.svg|250 px]]<br /><small> CAS-Nummer: 119618-22-3</small>
|}
==Reference==
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