Kanabinoidni receptor tip 1 — разлика између измена
Садржај обрисан Садржај додат
Спашавам 1 извора и означавам 0 мртвим. #IABot (v2.0beta14) |
м Бот: обликујем ISBN; козметичке измене |
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Ред 48:
CB<sub>1</sub> receptor se može modulisati putem [[Alosterna regulacija|alosternih]] sintetičkih liganda<ref name="pmid16113085">{{cite journal |vauthors=Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G, Westwood P, Marrs J, Thomson F, Cowley P, Christopoulos A, Pertwee RG, Ross RA | title = Allosteric modulation of the cannabinoid CB1 receptor | journal = Mol. Pharmacol. | volume = 68 | issue = 5 |pages= 1484–95 | year = 2005 | pmid = 16113085 | doi = 10.1124/mol.105.016162 | url = }}</ref> u pozitivnom<ref name="pmid19226282">{{cite journal |vauthors=Navarro HA, Howard JL, Pollard GT, Carroll FI | title = Positive allosteric modulation of the human cannabinoid (CB1) receptor by RTI-371, a selective inhibitor of the dopamine transporter | journal = Br. J. Pharmacol. | volume = 156 | issue = 7 |pages= 1178–84 | year = 2009 | pmid = 19226282 | pmc = 2697692 | doi = 10.1111/j.1476-5381.2009.00124.x | url = }}</ref> i negativnom<ref name="pmid17592509">{{cite journal |vauthors=Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P | title = PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats | journal = Br. J. Pharmacol. | volume = 152 | issue = 5 |pages= 805–14 | year = 2007 | pmid = 17592509 | pmc = 2190018 | doi = 10.1038/sj.bjp.0707347 | url = }}</ref> maniru. ''[[In vivo]]'' izlaganje [[Tetrahidrokanabinol|THC]] ligandu umanjuje [[dugotrajna potencijacija|dugotrajnu potencijaciju]] i dovodi do redukcije fosforilisanog [[CREB]].<ref name="neurochem">{{cite journal |vauthors=Fan N, Yang H, Zhang J, Chen C | title = Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Δ9-THC exposure-impaired hippocampal synaptic plasticity | journal = J. Neurochem. | volume = 112 | issue = 3 |pages= 691–702 | year = 2010 | pmid = 19912468 | pmc = 2809144 | doi = 10.1111/j.1471-4159.2009.06489.x | url = }}</ref>
Ukratko, aktivnost CB<sub>1</sub> receptora je spregnuta sa jonskim kanalima, na sledeći način:<ref name="pmid16570099"/>
* Pozitivno sa unutrašnje ispravljajućih i A-tipom izvoznih kalijumskih kanala.
* Negativno sa D-tipom izvoznih kalijumskih kanala
Ред 114:
* {{cite journal |vauthors=Mukhopadhyay S, Howlett AC |title=CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 499–505 |year= 2001 |pmid= 11168387 |doi=10.1046/j.1432-1327.2001.01810.x }}
* {{cite journal |last1=WJ|first1=Murphy|last2=E|first2=Eizirik|last3=WE|first3=Johnson|author4=''et al.'' |title=Molecular phylogenetics and the origins of placental mammals |journal=Nature |volume=409 |issue= 6820 |pages= 614–8 |year= 2001 |pmid= 11214319 |doi= 10.1038/35054550 }}
* {{cite journal |vauthors=Nong L, Newton C, Friedman H, Klein TW |title=CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types |journal=Adv. Exp. Med. Biol. |volume=493 |issue= |pages= 229–33 |year= 2002 |pmid= 11727770 |doi=10.1007/0-306-47611-8_27 | series=Advances in Experimental Medicine and Biology |id=ISBN 978-0-306-46466-
* {{cite journal |last1=S|first1=Leroy|last2=N|first2=Griffon|last3=MC|first3=Bourdel|author4=''et al.'' |title=Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1 |journal=Am. J. Med. Genet. |volume=105 |issue= 8 |pages= 749–52 |year= 2002 |pmid= 11803524 |doi=10.1002/ajmg.10038 }}
* {{cite journal |last1=LG|first1=Schmidt|last2=J|first2=Samochowiec|last3=U|first3=Finckh|author4=''et al.'' |title=Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence |journal=Drug and alcohol dependence |volume=65 |issue= 3 |pages= 221–4 |year= 2002 |pmid= 11841893 |doi=10.1016/S0376-8716(01)00164-8 }}
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