Propiltiouracil — разлика између измена
Садржај обрисан Садржај додат
мНема описа измене |
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Ред 54:
[[FDA]] je [[2009]]. objavila upozorenje kojim je informisala zdravstvene radnike o riziku od ozbiljnog oštećenja jetre, uključujući zatajenje jetre i smrt, pri upotrebu propiltiouracila.<ref>{{cite web|url=http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm162701.htm|title=Propylthiouracil (PTU)-Induced Liver Failure|publisher=[[FDA]]|accessdate=2009-05-03}}</ref> Posledica toga je da propiltiouracil nije više preporučen kao lek prvog izbora.<ref name="FDA PTU Guidelines">{{cite journal | url = http://www.liebertonline.com/doi/pdf/10.1089/thy.2009.0169 | pmid = 19583480 | doi=10.1089/thy.2009.0169 | volume=19 | issue=7 | title=The Role of Propylthiouracil in the Management of Graves' Disease in Adults: report of a meeting jointly sponsored by the American Thyroid Association and the Food and Drug Administration | year=2009 | month=July | journal=Thyroid | pages=673–4 | author=Bahn RS, Burch HS, Cooper DS, ''et al.''}}</ref>
==Hemijska sinteza==
Propiltiouracil se može pripremiti iz etil 3-oksoheksanoata i [[tioureja|tioureje]].<ref>{{Cite journal | doi=10.1021/ja01228a042 | title=Studies in Chemotherapy. X. Antithyroid Compounds. Synthesis of 5- and 6- Substituted 2-Thiouracils from β-Oxoesters and Thiourea | year=1945 | last1=Anderson | first1=George W. | last2=Halverstadt | first2=I. F.|last3=Miller | first3=Wilbur H. | last4=Roblin | first4=Richard O. | journal=Journal of the American Chemical Society | volume=67 | page=2197 | issue=12}}</ref>
:[[File:Propylthiouracil rxn.png|500px]]
==Reference==
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