Kvantitativni odnos strukture i aktivnosti — разлика између измена
Садржај обрисан Садржај додат
Нема описа измене |
м ispravke; козметичке измене |
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Ред 1:
Modeli '''kvantitativnog odnosa strukture i aktivnosti''' ({{jez-eng-lat|Quantitative structure–activity relationship}}) (
Na primer, biološka aktivnost se može kvantitativno izraziti kao koncentracija supstance neophodna da se proizvede dati biološki respons. Dodatno, kad su fizikohemijska svojstva ili strukture numerički izražene, moguće je utvrditi matematičku relaciju, ili kvantitativni odnos strukture i aktivnost, između njih. Matematički izraz se, ako je pažljivo testiran,<ref name = "Tropsha_2003">{{cite journal | author = Tropsha A, Gramatica P, Gombar VJ | title = The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models | journal = QSAR &Comb. Sci. | volume = 22 | pages = 69–77 | year = 2003 | doi = 10.1002/qsar.200390007 }}</ref><ref name = "Gramatica_2007">{{cite journal | author = Gramatica P | title = Principles of QSAR models validation: internal and external | journal = QSAR &Comb. Sci. | volume = 26 | pages = 694–701| year = 2007 | doi = 10.1002/qsar.200610151 }}</ref><ref name="Chirico_Gramatica_2012">{{cite journal | author = Chirico N, Gramatica P | title = Real external predictivity of QSAR models. Part 2. New intercomparable thresholds for different validation criteria and the need for scatter plot inspection | journal = J Chem Inf Model | volume = 52 | issue = 8 | pages = 2044–58 | year = 2012 | month = August | pmid = 22721530 | doi = 10.1021/ci300084j }}</ref> može zatim koristiti za predviđanje modelovanog responsa drugih hemijskih struktura, uz pažljivu proveru domena primenljivosti.
Ред 10:
== Reference ==
{{
== Literatura ==
Ред 18:
== Vidi još ==
* [[ADME]]
* [[Heminformatika]]
* [[Farmakokinetika]]
* [[Farmakofor]]
== Spoljašnje veze ==
* {{cite web | url = http://www.qsar.org/ | title = The Cheminformatics and QSAR Society | author = | authorlink = | coauthors = | date = | format = | work = | publisher = | pages = | language = | archiveurl = | archivedate = | quote = | accessdate =
* {{cite web | url = http://www.3d-qsar.com/ | title = The 3D QSAR Server | author = | authorlink = | coauthors = | date = | format = | work = | publisher = | pages = | language = | archiveurl = | archivedate = | quote = | accessdate =
* {{cite web | url = http://www.natureprotocols.com/2007/03/05/development_of_qsar_models_usi_1.php | title = Nature Protocols: Development of QSAR models using C-QSAR program | author = | authorlink = | coauthors = | date = | format = | work = | publisher = Nature Protocols | pages = | language = | archiveurl = | archivedate = | quote = A regression program that has dual databases of over 21,000 QSAR models | doi = 10.1038/nprot.2007.125 | accessdate =
* {{cite web | url = http://www.qsarworld.com | title = QSAR World | author = | authorlink = | coauthors = | date = | format = | work = | publisher = | pages = | language = | archiveurl = | archivedate = | quote = A comprehensive web resource for QSAR modelers | accessdate =
{{Medicinska hemija-lat}}
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