Arestin beta 1, ARRB1, je protein koji je čoveka kodiran ARRB1 genom.[1][2]

Arestin, beta 1
PDB prikaz baziran na 1g4m​.
Dostupne strukture
1g4m​, 1g4r​, 1jsy​, 1zsh
Identifikatori
Simboli ARRB1; ARB1; ARR1
Vanjski ID OMIM107940 MGI99473 HomoloGene2981 GeneCards: ARRB1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 408 109689
Ensembl ENSG00000137486 ENSMUSG00000018909
UniProt P49407 Q8BWG8
RefSeq (mRNA) NM_004041 NM_177231
RefSeq (protein) NP_004032 NP_796205
Lokacija (UCSC) Chr 11:
74.65 - 74.74 Mb
Chr 7:
99.41 - 99.48 Mb
PubMed pretraga [1] [2]

Funkcije

уреди

Za članove arestin/beta-arestin proteinske familije se smatra da učestvuju u agonistima posredovanoj desenzitizaciji G protein-spregnutih receptora i uzrokuju specifično prigušivanje ćelijskog responsa na stimuluse kao što su hormoni, neurotransmitera, ili senzorski signali. Arrestin beta 1 je citosolni protein koji deluje kao kofaktor u beta-adrenergičkom receptorskom kinazom (BARK) posredovanoj desenzitizaciji beta-adrenergičkog receptora. Pored centralnog nervnog sistema, on je izražen u visokim nivoima u perifernim krvnim leukocitima, i stoga se za BARK/beta-arestinski sistem da ima značajnu ulogu u regulaciji receptorom-posredovanih imunskih funkcija. Alternativno splajsovani transkripti kodiraju različite izoforme arestina beta 1. One su bile opisane, međutim, njihove precizne funkcije nisu poznate.[2]

Interakcije

уреди

Za arestin beta 1 je bilo pokazano da interaguje sa delta opioidnim receptorom,[3] Arf6,[4] paratiroidnom hormonu srodnim proteinom,[5] RALGDS,[6] PSCD2,[4] DVL2[7] i Mdm2.[8][9]

Reference

уреди
  1. ^ Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A (1993). „Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing”. The Journal of Biological Chemistry. 268 (13): 9753—61. PMID 8486659. Архивирано из оригинала 03. 01. 2005. г. Приступљено 04. 04. 2011. 
  2. ^ а б „Entrez Gene: ARRB1 arrestin, beta 1”. 
  3. ^ Cen, B; Yu Q (2001). „Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor”. J. Neurochem. United States. 76 (6): 1887—94. ISSN 0022-3042. PMID 11259507. doi:10.1046/j.1471-4159.2001.00204.x. 
  4. ^ а б Claing, A; Chen W (2001). „beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis”. J. Biol. Chem. United States. 276 (45): 42509—13. ISSN 0021-9258. PMID 11533043. doi:10.1074/jbc.M108399200. 
  5. ^ Conlan, Lindus A; Martin T John; Gillespie Matthew T (2002). „The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B”. FEBS Lett. Netherlands. 527 (1-3): 71—5. ISSN 0014-5793. PMID 12220636. doi:10.1016/S0014-5793(02)03164-2. 
  6. ^ Bhattacharya, Moshmi; Anborgh Pieter H; Babwah Andy V; Dale Lianne B; Dobransky Tomas; Benovic Jeffery L; Feldman Ross D; Verdi Joseph M; Rylett R Jane; Ferguson Stephen S G (2002). „Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization”. Nat. Cell Biol. England. 4 (8): 547—55. ISSN 1465-7392. PMID 12105416. doi:10.1038/ncb821. 
  7. ^ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (2001). „beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins”. Proc. Natl. Acad. Sci. U.S.A. United States. 98 (26): 14889—94. ISSN 0027-8424. PMC 64954 . PMID 11742073. doi:10.1073/pnas.211572798. 
  8. ^ Wang, Ping; Wu Yalan; Ge Xin; Ma Lan; Pei Gang (2003). „Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus”. J. Biol. Chem. United States. 278 (13): 11648—53. ISSN 0021-9258. PMID 12538596. doi:10.1074/jbc.M208109200. 
  9. ^ Shenoy, Sudha K; Xiao Kunhong; Venkataramanan Vidya; Snyder Peter M; Freedman Neil J; Weissman Allan M (2008). „Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor”. J. Biol. Chem. United States. 283 (32): 22166—76. ISSN 0021-9258. PMC 2494938 . PMID 18544533. doi:10.1074/jbc.M709668200. 

Literatura

уреди
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  • Parruti G; Peracchia F; Sallese M (1993). „Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.”. J. Biol. Chem. 268 (13): 9753—61. PMID 8486659. 
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