Receptor koagulacionog faktora II

Receptor koagulacionog faktora II, ili proteazom-aktivirani receptor‎‎ 1 (PAR1), je protein koji kod ljudi kodira F2R gen. PAR1 je G protein-spregnuti receptor koji učestvuje u regulaciji trombotskog responsa. Proteolitičko odsecanje dovodi do aktivacije receptora.

Receptor koagulacionog faktora II‎‎
Identifikatori
Simboli	F2R; CF2R; HTR; PAR1; TR
Vanjski ID	OMIM: 187930 MGI: 101802 HomoloGene: 1510 IUPHAR: PAR1 GeneCards: F2R Gene
Ontologija gena Molekularna funkcija • rodopsinu-slična receptorska aktivnost • receptorska aktivnost • receptorsko vezivanje • aktivnost trombinskog receptora Celularna komponenta • Goldžijev aparat • membrana plazme • integralno sa membranom plazme Biološki proces • regulacija progresa ćelijskog ciklusa • apoptoza • aktivacija kaspaze • ćelijska motilnost • prenos signala • signalni put G-protein spregnutog receptora • tirozinska fosforilacija STAT proteina • STAT proteinska jezgrena translokacija • razvoj multićelijskih organizama • koagulacija krvi • respons na ranjavanje • anatomska strukturna morfogeneza • pozitivna regulacija I-kapaB kinaze/NF-kapaB kaskade
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2149	14062
Ensembl	ENSG00000181104	ENSMUSG00000048376
UniProt	P25116	Q3UK34
RefSeq (mRNA)	NM_001992	NM_010169
RefSeq (protein)	NP_001983	NP_034299
Lokacija (UCSC)	Chr 5: 76.05 - 76.07 Mb	Chr 13: 96.7 - 96.72 Mb
PubMed pretraga	[1]	[2]

Ligandi

Nekoliko selektivnih antagonista PAR1 receptora je poznato. Oni se koriste kao antizgrušavajuća sredstva u lečenju bolesti srca.

• SCH-530348

Vidi još

• Proteazom-aktivirani receptor‎‎

Dodatna literatura

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