FZD9

Uvojiti receptor 9
Uvojiti receptor 9
Identifikatori
Simboli	FZD9; CD349; FZD3
Vanjski ID	OMIM: 601766 MGI: 1313278 HomoloGene: 2619 IUPHAR: FZD9 GeneCards: FZD9 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	8326
Ensembl	ENSG00000188763
UniProt	O00144
RefSeq (mRNA)	NM_003508.2
RefSeq (protein)	NP_003499.1
Lokacija (UCSC)	Chr 7:; 72.85 - 72.85 Mb
PubMed pretraga	[1]

Uvojiti-9 je protein koji je kod ljudi kodiran FZD9 genom.^[1]^[2]^[3] FZD9 se takođe označava kao CD349 (klaster diferencijacije 349).

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD4 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD9 gen je lociran unutar regiona na hromozomu 7 čije brisanje proizvodi Vilijamsonov sindrom. Heterozigotno brisanje FZD9 gena može da doprinese fenotipu Vilijamsovog sindroma. FZD9 je predominantno izražen u mozgu, testisima, očima, skeletalnim mišićima, i bubrezima.^[3]

Reference уреди

^ Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U (1997). „A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23”. Hum Mol Genet. 6 (3): 465—72. PMID 9147651. doi:10.1093/hmg/6.3.465.
^ Wang YK, Sporle R, Paperna T, Schughart K, Francke U (1999). „Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome”. Genomics. 57 (2): 235—48. PMID 10198163. doi:10.1006/geno.1999.5773.
^ ^а ^б „Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)”.

Literatura уреди

Datta DV (1977). „Viral hepatitis (Chandigarh study)”. The Journal of the Association of Physicians of India. 25 (5): 325—30. PMID 914765.
Finch PW; He X; Kelley MJ; et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233  . PMID 9192640. doi:10.1073/pnas.94.13.6770.
Tanaka S; Akiyoshi T; Mori M; et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164—9. PMC 21479  . PMID 9707618. doi:10.1073/pnas.95.17.10164.
Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (2002). „Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling”. J. Biol. Chem. 277 (40): 37479—86. PMID 12138115. doi:10.1074/jbc.M205658200.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
Omoto S; Hayashi T; Kitahara K; et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
Winn RA; Marek L; Han SY; et al. (2005). „Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation”. J. Biol. Chem. 280 (20): 19625—34. PMID 15705594. doi:10.1074/jbc.M409392200.
Rual JF; Venkatesan K; Hao T; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
Winn RA; Van Scoyk M; Hammond M; et al. (2006). „Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma”. J. Biol. Chem. 281 (37): 26943—50. PMID 16835228. doi:10.1074/jbc.M604145200.

Vidi još уреди

Uvojiti receptori

Spoljašnje veze уреди

„Frizzled Receptors: FZD₉”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 19. 03. 2012. г.
FZD9+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid9147651-1] Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U (1997). „A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23”. Hum Mol Genet. 6 (3): 465—72. PMID 9147651. doi:10.1093/hmg/6.3.465.

[pmid10198163-2] Wang YK, Sporle R, Paperna T, Schughart K, Francke U (1999). „Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome”. Genomics. 57 (2): 235—48. PMID 10198163. doi:10.1006/geno.1999.5773.

[entrez-3] а ^б „Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)”.

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[2]

[3]