GABRR2

GABRR2
Identifikatori
Alijasi	GABRR2
Spoljašnji ID	OMIM: 137162 MGI: 95626 HomoloGene: 20471 GeneCards: GABRR2
Genska lokacija (miš)
Hr.	Chromosome 4 (mouse)
Kraj	33,095,865 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• chloride channel activity; • extracellular ligand-gated ion channel activity; • GABA-A receptor activity; • ion channel activity; • transmembrane signaling receptor activity; • protein domain specific binding; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	• саставни део мембране; • GABA-A receptor complex; • postsynaptic membrane; • мембрана; • ћелијска мембрана; • синапса; • integral component of plasma membrane; • chloride channel complex; • cell junction; • neuron projection; • GABA-ergic synapse;
Biological process	• gamma-aminobutyric acid signaling pathway; • chloride transmembrane transport; • ion transport; • chloride transport; • GO:0072468 Prenos signala; • чуло вида; • chemical synaptic transmission; • ion transmembrane transport; • regulation of membrane potential; • процес нервног система; • regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Ortolozi
	2570
	14409
	ENSG00000111886
	ENSMUSG00000023267
	P28476
	P56476
	NM_002043
	NM_008076
	NP_002034
	NP_032102
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor gama-aminobutirne kiseline, podjedinica ro-2 je protein koji je kod ljudi kodiran GABRR2 genom.^[4]^[5]

GABA je jedan od glavnih inhibitornih neurotransmitera u mozgu sisara, gde deluje deluje na GABA receptorima, koji su ligandom kontrolisani hloridni kanali. GABRR2 je član ro potfamilije.^[5]

Vidi još

GABA_A-ρ receptor

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000023267 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (1992). „Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4”. Genomics. 12 (4): 801—6. PMID 1315307. doi:10.1016/0888-7543(92)90312-G.
^ ^а ^б „Entrez Gene: GABRR2 gamma-aminobutyric acid (GABA) receptor, rho 2”.

Literatura

Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). „The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.”. J. Biol. Chem. 272 (21): 13750—7. PMID 9153229. doi:10.1074/jbc.272.21.13750.
Kusama T, Hatama K, Sakurai M, et al. (1999). „Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.”. Neurosci. Lett. 255 (1): 17—20. PMID 9839716. doi:10.1016/S0304-3940(98)00696-X.
Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). „Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.”. Biochim. Biophys. Acta. 1447 (2–3): 307—12. PMID 10542332. doi:10.1016/S0167-4781(99)00167-0.
Billups D, Hanley JG, Orme M, et al. (2001). „GABAC receptor sensitivity is modulated by interaction with MAP1B”. J. Neurosci. 20 (23): 8643—50. PMID 11102469.
Sedelnikova A, Weiss DS (2002). „Phosphorylation of the recombinant rho1 GABA receptor”. Int. J. Dev. Neurosci. 20 (3–5): 237—46. PMID 12175859. doi:10.1016/S0736-5748(02)00037-0.
Croci C, Brändstatter JH, Enz R (2003). „ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2”. J. Biol. Chem. 278 (8): 6128—35. PMID 12431995. doi:10.1074/jbc.M205162200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Gamel-Didelon K, Kunz L, Fohr KJ, et al. (2003). „Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells”. J. Biol. Chem. 278 (22): 20192—5. PMID 12660236. doi:10.1074/jbc.M301729200.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.

Spoljašnje veze

GABRR2+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000023267 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1315307-4] Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (1992). „Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4”. Genomics. 12 (4): 801—6. PMID 1315307. doi:10.1016/0888-7543(92)90312-G.

[entrez-5] а ^б „Entrez Gene: GABRR2 gamma-aminobutyric acid (GABA) receptor, rho 2”.

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