GNAI1
GNAI1, Guanin nukleotid-vezujući protein G(i), alfa-1 podjedinica, je protein koji je kod ljudi kodiran GNAI1 genom.[1][2]
| Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 1agr. | |||||||||||
| Dostupne strukture | |||||||||||
| 1agr, 1as0, 1as2, 1as3, 1bh2, 1bof, 1cip, 1gdd, 1gfi, 1gg2, 1gia, 1gil, 1git, 1gp2, 1kjy, 1svk, 1svs, 1y3a, 2g83, 2gtp, 2hlb, 2ihb, 2ik8, 2ode | |||||||||||
| Identifikatori | |||||||||||
| Simboli | GNAI1; Gi | ||||||||||
| Vanjski ID | OMIM: 139310 MGI: 95771 HomoloGene: 74417 GeneCards: GNAI1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2770 | 14677 | |||||||||
| Ensembl | ENSG00000127955 | ENSMUSG00000057614 | |||||||||
| UniProt | P63096 | n/a | |||||||||
| RefSeq (mRNA) | NM_002069 | NM_010305 | |||||||||
| RefSeq (protein) | NP_002060 | NP_034435 | |||||||||
| Lokacija (UCSC) |
Chr 7: 79.6 - 79.69 Mb |
Chr 5: 17.78 - 17.87 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Interaktivna mapa signalnih puteva уреди
Kliknite na linkove gena, proteina i metabolita da prikažete članke.[3]
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Nikotin na dopaminergijskim neuronima uredi
Interakcije уреди
Za GNAI1 je bilo pokazano da ostvaruje interakcije sa GPR143,[4] RGS14,[5][6] RIC8A,[7] S1PR1,[8] RGS12[5] i RGS19.[9][10]
Reference уреди
- ^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (1987). „Human cDNA clones for an alpha subunit of Gi signal-transduction protein”. Proc Natl Acad Sci U S A. 84 (15): 5115—9. PMC 298804
. PMID 3110783. doi:10.1073/pnas.84.15.5115.
- ^ „Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1”.
- ^ The interactive pathway map can be edited at WikiPathways: „NicotineDopaminergic_WP1602”.
- ^ Schiaffino, M V; d'Addio M; et al. (1999). „Ocular albinism: evidence for a defect in an intracellular signal transduction system”. Nat. Genet. UNITED STATES. 23 (1): 108—12. ISSN 1061-4036. PMID 10471510. doi:10.1038/12715.
- ^ а б Kimple, R J; De Vries L; et al. (2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. United States. 276 (31): 29275—81. ISSN 0021-9258. PMID 11387333. doi:10.1074/jbc.M103208200.
- ^ Kimple, Randall J; Kimple Michelle E; et al. (2002). „Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits”. Nature. England. 416 (6883): 878—81. ISSN 0028-0836. PMID 11976690. doi:10.1038/416878a.
- ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.
- ^ Lee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. UNITED STATES. 271 (19): 11272—9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272.
- ^ Woulfe, D S; Stadel J M (1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. UNITED STATES. 274 (25): 17718—24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718.
- ^ De Vries, L; Elenko E; et al. (1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203—8. ISSN 0027-8424. PMC 26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203.
Literatura уреди
- Sidhu A, Niznik HB (2000). „Coupling of dopamine receptor subtypes to multiple and diverse G proteins.”. Int. J. Dev. Neurosci. 18 (7): 669—77. PMID 10978845. doi:10.1016/S0736-5748(00)00033-2.
- Brown EJ, Frazier WA (2001). „Integrin-associated protein (CD47) and its ligands.”. Trends Cell Biol. 11 (3): 130—5. PMID 11306274. doi:10.1016/S0962-8924(00)01906-1.
- Raymond JR; Mukhin YV; Gelasco A; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179—212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3.
- Jiang M, Pandey S, Tran VT, Fong HK (1991). „Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.”. Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907—11. PMC 51562 . PMID 1902575. doi:10.1073/pnas.88.9.3907.
- Gennity JM, Siess W (1991). „Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.”. Biochem. J. 279 ( Pt 3): 643—50. PMC 1151493 . PMID 1953657.
- Itoh H; Toyama R; Kozasa T; et al. (1988). „Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.”. J. Biol. Chem. 263 (14): 6656—64. PMID 2834384.
- Bloch DB; Bloch KD; Iannuzzi M; et al. (1988). „The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.”. Am. J. Hum. Genet. 42 (6): 884—8. PMC 1715192 . PMID 3130752.
- Nagata K; Katada T; Tohkin M; et al. (1988). „GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin.”. FEBS Lett. 237 (1-2): 113—7. PMID 3139448. doi:10.1016/0014-5793(88)80182-0.
- Kagimoto S; Yamada Y; Kubota A; et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188—95. PMID 7914078. doi:10.1006/bbrc.1994.2054.
- Nitta K; Uchida K; Kawashima A; et al. (1994). „Identification of GTP-binding proteins in human glomeruli.”. Nippon Jinzo Gakkai shi. 36 (1): 9—12. PMID 8107314.
- Law SF; Zaina S; Sweet R; et al. (1994). „Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.”. Mol. Pharmacol. 45 (4): 587—90. PMID 8183236.
- Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). „Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.”. Endocrinology. 132 (6): 2484—90. PMID 8504751. doi:10.1210/en.132.6.2484.
- Laugwitz KL; Allgeier A; Offermanns S; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC 40189 . PMID 8552586. doi:10.1073/pnas.93.1.116.
- Andersson B; Wentland MA; Ricafrente JY; et al. (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138.
- Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”. J. Biol. Chem. 271 (19): 11272—9. PMID 8626678. doi:10.1074/jbc.271.19.11272.
- De Vries L; Elenko E; Hubler L; et al. (1997). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203—8. PMC 26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203.
- Yu W; Andersson B; Worley KC; et al. (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. PMC 139146 . PMID 9110174.
- Popov S, Yu K, Kozasa T, Wilkie TM (1997). „The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.”. Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216—20. PMC 23796 . PMID 9207071. doi:10.1073/pnas.94.14.7216.
- Shuey DJ; Betty M; Jones PG; et al. (1998). „RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.”. J. Neurochem. 70 (5): 1964—72. PMID 9572280. doi:10.1046/j.1471-4159.1998.70051964.x.