Prostaglandinski E receptor 3

Prostaglandinski E receptor 3 (EP₃) je prostaglandinski receptor, kodiran PTGER3 genom.

Prostaglandinski E receptor 3
Identifikatori
Simboli	PTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2-R
Vanjski ID	OMIM: 176806 MGI: 97795 HomoloGene: 105703 IUPHAR: EP3 GeneCards: PTGER3 Gene
Ontologija gena Molekularna funkcija • ligandom aktivirano za sekvencu specifično DNK vezivanje RNK polimeraze II transkriptnog faktora • aktivnost prostaglandinskog E receptora Celularna komponenta • nuklearna koverta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • transkripcija, DNK-zavisna • signalni put G-protein spregnutog receptora • biološki proces • ćelijska smrt
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	5733	19218
Ensembl	ENSG00000050628	ENSMUSG00000040016
UniProt	P43115	Q6PDF2
RefSeq (mRNA)	NM_000957.2	NM_011196.2
RefSeq (protein)	NP_001119516.1	NP_035326.2
Lokacija (UCSC)	Chr 1: 71.32 - 71.51 Mb	Chr 3: 157.23 - 157.31 Mb
PubMed pretraga	[1]	[2]

Receptor

Ovaj protein je član familije G protein spregnutih receptora. On je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). Ovaj receptor ima mnoštvo bioloških funkcija, što obuhvata varenje, nervni sistem, bubrežnu reapsorpciju, i aktivnosti materičnih kontrakcija. U stomaku, on inhibira lučenje želudačne kiseline.

Ispitivanja na miševima sugeriraju da ovaj receptor takođe posreduje odgovor na adrenokortikotropni hormon kao i formiranje groznice.

Varijacije

Više alternativno splajsovanih transkriptnih varijanti kodira osam distinktnih izoformi.

Literatura

• Kotani M; Tanaka I; Ogawa Y; et al. (1995). „Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions”. Mol. Pharmacol. 48 (5): 869—79. PMID 7476918. 
• Duncan AM; Anderson LL; Funk CD; et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family”. Genomics. 25 (3): 740—742. PMID 7759114. doi:10.1016/0888-7543(95)80022-E. 
• Schmid A, Thierauch KH, Schleuning WD, Dinter H (1995). „Splice variants of the human EP3 receptor for prostaglandin E2”. Eur. J. Biochem. 228 (1): 23—30. PMID 7883006. doi:10.1111/j.1432-1033.1995.tb20223.x. 
• An S; Yang J; So SW; et al. (1995). „Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals”. Biochemistry. 33 (48): 14496—14502. PMID 7981210. doi:10.1021/bi00252a016. 
• Regan JW; Bailey TJ; Donello JE; et al. (1994). „Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini”. Br. J. Pharmacol. 112 (2): 377—85. PMC 1910333 . PMID 8075855. 
• Yang J, Xia M, Goetzl EJ, An S (1994). „Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2”. Biochem. Biophys. Res. Commun. 198 (3): 999—1006. PMID 8117308. doi:10.1006/bbrc.1994.1142. 
• Kunapuli SP; Fen Mao G; Bastepe M; et al. (1994). „Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells”. Biochem. J. 298 (2): 263—7. PMC 1137934 . PMID 8135729. 
• Adam M; Boie Y; Rushmore TH; et al. (1994). „Cloning and expression of three isoforms of the human EP3 prostanoid receptor”. FEBS Lett. 338 (2): 170—174. PMID 8307176. doi:10.1016/0014-5793(94)80358-7. 
• Chang C, Negishi M, Nishigaki N, Ichikawa A (1997). „Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype”. Biochem. J. 322 (2): 597—601. PMC 1218231 . PMID 9065782. 
• Kotani M; Tanaka I; Ogawa Y; et al. (1997). „Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)”. Genomics. 40 (3): 425—434. PMID 9073510. doi:10.1006/geno.1996.4585. 
• Ushikubi F; Segi E; Sugimoto Y; et al. (1998). „Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3”. Nature. 395 (6699): 281—284. PMID 9751056. doi:10.1038/26233. 
• Bhattacharya M; Peri K; Ribeiro-da-Silva A; et al. (1999). „Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope”. J. Biol. Chem. 274 (22): 15719—15724. PMID 10336471. doi:10.1074/jbc.274.22.15719. 
• Liu J; Akahoshi T; Jiang S; et al. (2000). „Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3”. J. Leukoc. Biol. 68 (2): 187—93. PMID 10947062. 
• Kurihara Y, Endo H, Kondo H (2001). „Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells”. Inflamm. Res. 50 (1): 1—5. PMID 11235015. doi:10.1007/s000110050716. 
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 
• Matsuoka Y; Furuyashiki T; Bito H; et al. (2003). „Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes”. Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132—4137. PMC 153060 . PMID 12642666. doi:10.1073/pnas.0633341100. 
• Wing DA; Goharkhay N; Hanna M; et al. (2003). „EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium”. J. Soc. Gynecol. Investig. 10 (3): 124—129. PMID 12699873. doi:10.1016/S1071-5576(03)00007-8. 
• Abulencia JP; Gaspard R; Healy ZR; et al. (2003). „Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells”. J. Biol. Chem. 278 (31): 28388—28394. PMID 12743126. doi:10.1074/jbc.M301378200. 
• Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes”. J. Clin. Endocrinol. Metab. 88 (6): 2810—2816. PMID 12788892. doi:10.1210/jc.2002-021475. 
• Moreland RB; Kim N; Nehra A; et al. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum”. Int. J. Impot. Res. 15 (5): 362—368. PMID 14562138. doi:10.1038/sj.ijir.3901042. 

Vidi još

• Eikozanoidni receptor

Spoljašnje veze

• „Prostanoid Receptors: EP₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 29. 06. 2016. г.